The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells
Open accessAbstract
The nuclear hormone receptor retinoic acid receptor–related orphan receptor γt (RORγt) is required for the generation of T helper 17 cells expressing the proinflammatory cytokine interleukin (IL)-17. In vivo, however, less than half of RORγt+ T cells express IL-17. We report here that RORγt+ Tαβ cells include Foxp3+ cells that coexist with IL-17–producing RORγt+ Tαβ cells in all tissues examined. The Foxp3+ RORγt+ Tαβ express IL-10 and CCL20, and function as regulatory T cells. Furthermore, the ratio of Foxp3+ to IL-17–producing RORγt+ Tαβ cells remains remarkably constant in mice enduring infection and inflammation. This equilibrium is tuned in favor of IL-10 production by Foxp3 and CCL20, and in favor of IL-17 production by IL-6 and IL-23. In the lung and skin, the largest population of RORγt+ T cells express the γδ T cell receptor and produce the highest levels of IL-17 independently of IL-6. Thus, potentially antagonistic proinflammatory IL-17–producing and regulatory Foxp3+ RORγt+ T cells coexist and are tightly controlled, suggesting that a perturbed equilibrium in RORγt+ T cells might lead to decreased immunoreactivity or, in contrast, to pathological inflammation.
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Cites
1 retracted
Inducible costimulator is essential for collagen-induced arthritis
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Cited by
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Self-citationGeneration of pathogenic TH17 cells in the absence of TGF-β signalling
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The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
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“In these animals, the functions of TH17 cells (CD4RORγt cells) and other RORγt-expressing αβT cells are inhibited, but there is no effect in RORγtexpressing innate (or innate-like) immune cells, including γδT, lymphoid tissue-inducer (LTi) cells, and innate lymphoid cells type 3 (ILC3) (11, 12), as well as in RORγexpr…”
Background
Metadata
- Authors
- Lochner, M., Peduto, L., Cherrier, M., Sawa, S., Langa, F., Varona, R., Riethmacher, D., Si-Tahar, M., Di Santo, J. P., & Eberl, G.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2008-05-26
- Volume
- 205
- Issue
- 6
- Pages
- 1381-1393
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1977181138
- Cited by
- 542
- References
- 63
- FWCI
- 17.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lochner, M., Peduto, L., Cherrier, M., Sawa, S., Langa, F., Varona, R., Riethmacher, D., Si-Tahar, M., Di Santo, J. P., & Eberl, G. (2008). In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20080034
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
