The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics
Open accessAbstract
The sphingosine 1-phosphate receptor 1 (S1P1) promotes lymphocyte egress from lymphoid organs. Previous work showed that agonist-induced internalization of this G protein–coupled receptor correlates with inhibition of lymphocyte egress and results in lymphopenia. However, it is unclear if S1P1 internalization is necessary for this effect. We characterize a knockin mouse (S1p1rS5A/S5A) in which the C-terminal serine-rich S1P1 motif, which is important for S1P1 internalization but dispensable for S1P1 signaling, is mutated. T cells expressing the mutant S1P1 showed delayed S1P1 internalization and defective desensitization after agonist stimulation. Mutant mice exhibited significantly delayed lymphopenia after S1P1 agonist administration or disruption of the vascular S1P gradient. Adoptive transfer experiments demonstrated that mutant S1P1 expression in lymphocytes, rather than endothelial cells, facilitated this delay in lymphopenia. Thus, cell-surface residency of S1P1 on T cells is a primary determinant of lymphocyte egress kinetics in vivo.
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Cites
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
Matloubian, M., Lo, C. G., Cinamon, G., Lesneski, M. J., Xu, Y., Brinkmann, V., Allende, M. L., Proia, R. L., & Cyster, J. G. (2004) · Nature · doi:10.1038/nature02284 · Cited by 2,581
Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
Cyster, J. G. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115628 · Cited by 856
The alliance of sphingosine-1-phosphate and its receptors in immunity
Rivera, J., Proia, R. L., & Olivera, A. (2008) · Nature Reviews Immunology · doi:10.1038/nri2400 · Cited by 616
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis
Ishii, M., Egen, J. G., Klauschen, F., Meier-Schellersheim, M., Saeki, Y., Vacher, J., Proia, R. L., & Germain, R. N. (2009) · Nature · doi:10.1038/nature07713 · Cited by 515
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Metadata
- Authors
- Thangada, S., Khanna, K. M., Blaho, V. A., Oo, M. L., Im, D.-S., Guo, C., Lefrancois, L., & Hla, T.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2010-06-28
- Volume
- 207
- Issue
- 7
- Pages
- 1475-1483
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2161804483
- Cited by
- 172
- References
- 4
- FWCI
- 6.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Thangada, S., Khanna, K. M., Blaho, V. A., Oo, M. L., Im, D.-S., Guo, C., Lefrancois, L., & Hla, T. (2010). Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20091343
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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