Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
Abstract
▪ Abstract Secondary lymphoid organs serve as hubs for the adaptive immune system, bringing together antigen, antigen-presenting cells, and lymphocytes. Two families of G protein–coupled receptors play essential roles in lymphocyte migration through these organs: chemokine receptors and sphingosine-1-phosphate (S1P) receptors. Chemokines expressed by lymphoid stromal cells guide lymphocyte and dendritic cell movements during antigen surveillance and the initiation of adaptive immune responses. S1P receptor-1 is required for lymphocyte egress from thymus and secondary lymphoid organs and is downregulated by the immunosuppressive drug FTY720. Here, we review the steps associated with the initiation of adaptive immune responses in secondary lymphoid organs, highlighting the roles of chemokines and S1P.
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FTY720 blocks migration of T cells and ILCs from circulation into the skin by impairing S1PR1-mediated signals.
“FTY720 blocks the migration of T cells and ILCs from circulation into the skin by impairing sphingosine-1-phosphate receptor 1 (S1PR1)-mediated signals.18,19”
From Skin-resident T cells play an important role in controlling skin colonization of Candidozyma (Candida) auris (2026) · cites this paper as [18]
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- Authors
- Cyster, J. G.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Cyster, Jason G.
- ORCID
- Cyster, Jason G.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2005-04-01
- Volume
- 23
- Issue
- 1
- Pages
- 127-159
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2097302710
- Cited by
- 856
- References
- 0
- Citations by year
- 2026: 15 · 2025: 7 · 2024: 16 · 2023: 12 · 2022: 19 · 2021: 14 · 2020: 19 · 2019: 34 · 2018: 27 · 2017: 24 · 2016: 29 · 2015: 35 · 2014: 46 · 2013: 60 · 2012: 62
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Langley Research Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- chemokines, chemokine receptors, sphingosine-1-phosphate, S1P receptors, S1P1 receptor, lymphocyte migration, secondary lymphoid organs, dendritic cells, lymphocyte egress, thymus, fingolimod, immunosuppression, lymphoid stromal cells
- MeSH terms
- Fingolimod Hydrochloride, Adaptation, Physiological, Animals, Antigen-Presenting Cells, Cell Movement, Humans, Immunosuppressive Agents, Lymphocyte Activation, Lymphocytes, Lymphoid Tissue, Lysophospholipids, Plasma Cells, Propylene Glycols, Sphingosine, Models, Immunological, Chemokines, Receptors, Chemokine
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