The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells
Open accessAbstract
Mucosal vaccination via the respiratory tract can elicit protective immunity in animal infection models, but the underlying mechanisms are still poorly understood. We show that a single intranasal application of the replication-deficient modified vaccinia virus Ankara, which is widely used as a recombinant vaccination vector, results in prominent induction of bronchus-associated lymphoid tissue (BALT). Although initial peribronchiolar infiltrations, characterized by the presence of dendritic cells (DCs) and few lymphocytes, can be found 4 d after virus application, organized lymphoid structures with segregated B and T cell zones are first observed at day 8. After intratracheal application, in vitro–differentiated, antigen-loaded DCs rapidly migrate into preformed BALT and efficiently activate antigen-specific T cells, as revealed by two-photon microscopy. Furthermore, the lung-specific depletion of DCs in mice that express the diphtheria toxin receptor under the control of the CD11c promoter interferes with BALT maintenance. Collectively, these data identify BALT as tertiary lymphoid structures supporting the efficient priming of T cell responses directed against unrelated airborne antigens while crucially requiring DCs for its sustained presence.
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Cites
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Self-citationRole of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity
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Cited by
Ectopic lymphoid-like structures in infection, cancer and autoimmunity
Pitzalis, C., Jones, G. W., Bombardieri, M., & Jones, S. A. (2014) · Nature Reviews Immunology · doi:10.1038/nri3700 · Cited by 698
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Siliņa, K., Soltermann, A., Attar, F. M., Casanova, R., Uckeley, Z. M., Thut, H., Wandres, M., Isajevs, S., Cheng, P., Curioni-Fontecedro, A., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-1987 · Cited by 448
The development of inducible bronchus-associated lymphoid tissue depends on IL-17
Rangel-Moreno, J., Carragher, D. M., de la Luz Garcia-Hernandez, M., Hwang, J. Y., Kusser, K., Hartson, L., Kolls, J. K., Khader, S. A., & Randall, T. D. (2011) · Nature Immunology · doi:10.1038/ni.2053 · Cited by 441
Tertiary lymphoid structures, drivers of the anti‐tumor responses in human cancers
Dieu‐Nosjean, M., Giraldo, N. A., Kaplon, H., Germain, C., Fridman, W. H., & Sautès‐Fridman, C. (2016) · Immunological Reviews · doi:10.1111/imr.12405 · Cited by 417
Metadata
- Authors
- Halle, S., Dujardin, H. C., Bakocevic, N., Fleige, H., Danzer, H., Willenzon, S., Suezer, Y., Hämmerling, G., Garbi, N., Sutter, G., Worbs, T., & Förster, R.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2009-11-16
- Volume
- 206
- Issue
- 12
- Pages
- 2593-2601
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2080798548
- Cited by
- 295
- References
- 21
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Halle, S., Dujardin, H. C., Bakocevic, N., Fleige, H., Danzer, H., Willenzon, S., Suezer, Y., Hämmerling, G., Garbi, N., Sutter, G., Worbs, T., & Förster, R. (2009). Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20091472
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