CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions
Open accessAbstract
The CC chemokine receptor CCR7 has been identified as a key regulator of homeostatic B and T cell trafficking to secondary lymphoid organs. Data presented here demonstrate that CCR7 is also an essential mediator for entry of both dermal and epidermal dendritic cells (DC) into the lymphatic vessels within the dermis while this receptor is dispensable for the mobilization of Langerhans cells from the epidermis to the dermis. Moreover, a distinct population of CD11c(+)MHCII(high) DC showing low expression of the costimulatory molecules CD40, CD80, and CD86 in wild-type animals was virtually absent in skin-draining lymph nodes of CCR7-deficient mice under steady-state conditions. We provide evidence that these cells represent a semimature population of DC that is capable of initiating T cell proliferation under conditions known to induce tolerance. Thus, our data identify CCR7 as a key regulator that governs trafficking of skin DC under both inflammatory and steady-state conditions.
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CCR7 is expressed constitutively by most T cells and is induced on DCs by inflammation.
“The CCL21 receptor, CCR7, is expressed constitutively by most T cells and is induced on DCs by inflammation (98, 100).”
From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [100]
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- Authors
- Ohl, L., Mohaupt, M., Czeloth, N., Hintzen, G., Kiafard, Z., Zwirner, J., Blankenstein, T., Henning, G., & Förster, R.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Max Delbrück Center (DE)
- University of Göttingen (DE)
- Corresponding author
- Förster, Reinhold
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 21
- Issue
- 2
- Pages
- 279-288
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2169390260
- Cited by
- 1,086
- References
- 0
- Citations by year
- 2026: 31 · 2025: 37 · 2024: 43 · 2023: 40 · 2022: 49 · 2021: 51 · 2020: 47 · 2019: 62 · 2018: 41 · 2017: 59 · 2016: 55 · 2015: 43 · 2014: 48 · 2013: 59 · 2012: 49
- FWCI
- 23.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- GRO (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- CCR7, dermal dendritic cells, dendritic cell migration, Langerhans cells, skin-draining lymph nodes, T cell tolerance, chemokine receptors, steady-state immunity, inflammation
- MeSH terms
- Animals, Histocompatibility Antigens Class II, Cell Division, Cell Movement, Dendritic Cells, Inflammation, Langerhans Cells, T-Lymphocytes, Receptors, Chemokine, CD11c Antigen, Mice, Receptors, CCR7
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