The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon
Open accessAbstract
Dendritic cells (DCs) and macrophages (MPs) are important for immunological homeostasis in the colon. We found that F4/80hiCX3CR1hi (CD11b+CD103−) cells account for 80% of mouse colonic lamina propria MHC-IIhi cells. Both CD11c+ and CD11c− cells within this population were identified as MPs based on multiple criteria, including an MP transcriptome revealed by microarray analysis. These MPs constitutively released high levels of IL-10 at least partially in response to the microbiota via an MyD88-independent mechanism. In contrast, cells expressing low to intermediate levels of F4/80 and CX3CR1 were identified as DCs based on phenotypic and functional analysis and comprise three separate CD11chi cell populations: CD103+CX3CR1−CD11b− DCs, CD103+CX3CR1−CD11b+ DCs, and CD103−CX3CR1intCD11b+ DCs. In noninflammatory conditions, Ly6Chi monocytes (MOs) differentiated primarily into CD11c+ but not CD11c− MPs. In contrast, during colitis, Ly6Chi MOs massively invaded the colon and differentiated into proinflammatory CD103−CX3CR1intCD11b+ DCs, which produced high levels of IL-12, IL-23, iNOS, and TNF. These findings demonstrate the dual capacity of Ly6Chi blood MOs to differentiate into either regulatory MPs or inflammatory DCs in the colon and that the balance of these immunologically antagonistic cell types is dictated by microenvironmental conditions.
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“1 (A20), CD14 (Sa2-8), Mac3 (M3/84), CD70 (FR70), CD71 (C2), CD115 (AFS98), CCR6 (clone 140706; R&D Systems), CCR7 (4B12), CD25 (7D4), CD40 (3/23), CD69 (H1.”
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Cited by
Macrophage biology in development, homeostasis and disease
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Intestinal epithelial cells: regulators of barrier function and immune homeostasis
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Role of the normal gut microbiota
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From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
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Metadata
- Authors
- Rivollier, A., He, J., Kole, A., Valatas, V., & Kelsall, B. L.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2012-01-09
- Volume
- 209
- Issue
- 1
- Pages
- 139-155
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2150781849
- Cited by
- 549
- References
- 57
- FWCI
- 25.64
- Type
- journal article
- Language
- en
- Open access
- green
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