The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think
Open accessAbstract
Notch signaling is often considered a model hematopoietic proto-oncogene because of its role as the main trigger of T cell acute lymphoblastic leukemia (T-ALL). Although its role in T-ALL is well characterized and further supported by a high frequency of activating NOTCH1 mutations in T-ALL patients, it still remains an open question whether the effects of Notch signaling are causative in other types of cancer, including solid tumors. Growing evidence supported by recent studies unexpectedly shows that Notch signaling can also have a potent tumor suppressor function in both solid tumors and hematological malignancies. We discuss the intriguing possibility that the pleiotropic functions of Notch can be tumor suppressive or oncogenic depending on the cellular context.
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Cites
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
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The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
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Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1
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Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Puente, X. S., Pinyol, M., Quesada, V., Conde, L., Ordóñez, G. R., Villamor, N., Escaramis, G., Jares, P., Beà, S., González-Díaz, M., et al. (2011) · Nature · doi:10.1038/nature10113 · Cited by 1,514
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
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Self-citationNotch1 functions as a tumor suppressor in mouse skin
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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
Weng, A. P., Millholland, J. M., Yashiro-Ohtani, Y., Arcangeli, M. L., Lau, A., Wai, C., del Bianco, C., Rodriguez, C. G., Sai, H., Tobias, J., et al. (2006) · Genes & Development · doi:10.1101/gad.1450406 · Cited by 870
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
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Non-coding recurrent mutations in chronic lymphocytic leukaemia
Puente, X. S., Beà, S., Valdés-Mas, R., Villamor, N., Gutiérrez-Abril, J., Martín-Subero, J. I., Munar, M., Rubio-Pérez, C., Jares, P., Aymerich, M., et al. (2015) · Nature · doi:10.1038/nature14666 · Cited by 829
Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts
Kode, A., Manavalan, J. S., Mosialou, I., Bhagat, G., Rathinam, C. V., Luo, N., Khiabanian, H., Lee, A., Murty, V. V., Friedman, R., et al. (2014) · Nature · doi:10.1038/nature12883 · Cited by 532
Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
Shi, Q., Xue, C., Zeng, Y., Yuan, X., Chu, Q., Jiang, S., Wang, J., Zhang, Y., Zhu, D., & Li, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01828-x · Cited by 401
Prognostic relevance of genetic alterations in diffuse lower-grade gliomas
Aoki, K., Nakamura, H., Suzuki, H., Matsuo, K., Kataoka, K., Shimamura, T., Motomura, K., Ohka, F., Shiina, S., Yamamoto, T., et al. (2018) · Neuro-Oncology · doi:10.1093/neuonc/nox132 · Cited by 307
Metadata
- Authors
- Lobry, C., Oh, P., & Aifantis, I.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2011-09-26
- Volume
- 208
- Issue
- 10
- Pages
- 1931-1935
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2105666596
- Cited by
- 356
- References
- 31
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think. https://app.cochat.ai/papers/10.1084/jem.20111855
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- Lobry, C., Oh, P., & Aifantis, I. (2011). Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20111855
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
