The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Neural reflexes in inflammation and immunity
Open accessAbstract
The mammalian immune system and the nervous system coevolved under the influence of infection and sterile injury. Knowledge of homeostatic mechanisms by which the nervous system controls organ function was originally applied to the cardiovascular, gastrointestinal, musculoskeletal, and other body systems. Development of advanced neurophysiological and immunological techniques recently enabled the study of reflex neural circuits that maintain immunological homeostasis, and are essential for health in mammals. Such reflexes are evolutionarily ancient, dating back to invertebrate nematode worms that possess primitive immune and nervous systems. Failure of these reflex mechanisms in mammals contributes to nonresolving inflammation and disease. It is also possible to target these neural pathways using electrical nerve stimulators and pharmacological agents to hasten the resolution of inflammation and provide therapeutic benefit.
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Cites
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BackgroundInfluentialSelf-citationAcetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit
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Cited by
Koopman, F. A., Chavan, S. S., Miljko, S., Grazio, S., Sokolovic, S., Schuurman, P. R., Mehta, A. D., Levine, Y. A., Faltys, M., Zitnik, R., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605635113 · Cited by 1,024
Self-citationRole of pyroptosis in inflammation and cancer
Wei, X., Xie, F., Zhou, X., Wu, Y., Yan, H., Liu, T., Huang, J., Wang, F., Zhou, F., & Zhang, L. (2022) · Cellular & Molecular Immunology · doi:10.1038/s41423-022-00905-x · Cited by 699
The hierarchical basis of neurovisceral integration
Smith, R., Thayer, J. F., Khalsa, S. S., & Lane, R. D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.003 · Cited by 523
A jump-start for electroceuticals
Famm, K., Litt, B., Tracey, K. J., Boyden, E. S., & Slaoui, M. (2013) · Nature · doi:10.1038/496159a · Cited by 554
Self-citationA body–brain circuit that regulates body inflammatory responses
Jin, H., Li, M., Jeong, E., Castro-Martinez, F., & Zuker, C. S. (2024) · Nature · doi:10.1038/s41586-024-07469-y · Cited by 383
Metadata
- Authors
- Andersson, U., & Tracey, K. J.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2012-06-04
- Volume
- 209
- Issue
- 6
- Pages
- 1057-1068
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2169567979
- Cited by
- 378
- References
- 23
- FWCI
- 11.68
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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