The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Alveolar macrophage–derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes
Open accessAbstract
Type I interferons (IFNs) are important for host defense from viral infections, acting to restrict viral production in infected cells and to promote antiviral immune responses. However, the type I IFN system has also been associated with severe lung inflammatory disease in response to respiratory syncytial virus (RSV). Which cells produce type I IFNs upon RSV infection and how this directs immune responses to the virus, and potentially results in pathological inflammation, is unclear. Here, we show that alveolar macrophages (AMs) are the major source of type I IFNs upon RSV infection in mice. AMs detect RSV via mitochondrial antiviral signaling protein (MAVS)–coupled retinoic acid–inducible gene 1 (RIG-I)–like receptors (RLRs), and loss of MAVS greatly compromises innate immune restriction of RSV. This is largely attributable to loss of type I IFN–dependent induction of monocyte chemoattractants and subsequent reduced recruitment of inflammatory monocytes (infMo) to the lungs. Notably, the latter have potent antiviral activity and are essential to control infection and lessen disease severity. Thus, infMo recruitment constitutes an important and hitherto underappreciated, cell-extrinsic mechanism of type I IFN–mediated antiviral activity. Dysregulation of this system of host antiviral defense may underlie the development of RSV-induced severe lung inflammation.
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Cites
Monocyte recruitment during infection and inflammation
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Self-citationPan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
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TLR4 Polymorphisms Mediate Impaired Responses to Respiratory Syncytial Virus and Lipopolysaccharide
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Cited by
Shared and Distinct Functions of Type I and Type III Interferons
Lazear, H. M., Schoggins, J. W., & Diamond, M. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.025 · Cited by 1,138
Early local immune defences in the respiratory tract
Iwasaki, A., Foxman, E. F., & Molony, R. D. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.117 · Cited by 328
Cloonan, S. M., & Choi, A. M. K. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81113 · Cited by 322
Molecular and epigenetic basis of macrophage polarized activation
Porta, C., Riboldi, E., Ippolito, A., & Sica, A. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.10.003 · Cited by 320
Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation
Toussaint, M., Jackson, D. J., Swieboda, D., Guedán, A., Tsourouktsoglou, T.-D., Ching, Y. M., Radermecker, C., Makrinioti, H., Aniscenko, J., Bartlett, N. W., et al. (2017) · Nature Medicine · doi:10.1038/nm.4332 · Cited by 319
Metadata
- Authors
- Goritzka, M., Makris, S., Kausar, F., Durant, L. R., Pereira, C., Kumagai, Y., Culley, F. J., Mack, M., Akira, S., & Johansson, C.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2015-04-20
- Volume
- 212
- Issue
- 5
- Pages
- 699-714
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2110812524
- Cited by
- 279
- References
- 6
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Goritzka, M., Makris, S., Kausar, F., Durant, L. R., Pereira, C., Kumagai, Y., Culley, F. J., Mack, M., Akira, S., & Johansson, C. (2015). Alveolar macrophage–derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20140825
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