Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996 · see citing works

STRING v9.1: protein-protein interaction networks, with increased coverage and integration

Franceschini, A., Szklarczyk, D., Frankild, S., Kuhn, M., Simonovic, M., Roth, A., Lin, J., Minguez, P., Bork, P., von Mering, C., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1094 · Cited by 4,398 · see citing works

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

Wu, J., Sun, L., Chen, X., Du, F., Shi, H., Chen, C., & Chen, Z. J. (2012) · Science · doi:10.1126/science.1229963 · Cited by 2,574 · see citing works

A diverse range of gene products are effectors of the type I interferon antiviral response

Schoggins, J. W., Wilson, S. J., Panis, M., Murphy, M. Y., Jones, C. T., Bieniasz, P. D., & Rice, C. M. (2011) · Nature · doi:10.1038/nature09907 · Cited by 2,439 · see citing works

Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays

Der, S. D., Zhou, A., Williams, B. R. G., & Silverman, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15623 · Cited by 1,805 · see citing works

Interferon-stimulated genes and their antiviral effector functions

Schoggins, J. W., & Rice, C. M. (2011) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.10.008 · Cited by 1,296 · see citing works

Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

Gao, P., Ascano, M., Wu, Y., Barchet, W., Gaffney, B. L., Zillinger, T., Serganov, A. A., Liu, Y., Jones, R. A., Hartmann, G., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.046 · Cited by 1,101 · see citing works

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

Li, X.-D., Wu, J., Gao, D., Wang, H., Sun, L., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1244040 · Cited by 1,097 · see citing works

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

Gao, D., Wu, J., Wu, Y.-T., Du, F., Aroh, C., Yan, N., Sun, L., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1240933 · Cited by 986 · see citing works

Functional classification of interferon-stimulated genes identified using microarrays

de Veer, M. J., Holko, M., Frevel, M. A. E., Walker, E. M., Der, S., Paranjape, J. M., Silverman, R. H., & Williams, B. R. G. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.6.912 · Cited by 902 · see citing works

Structural mechanism of cytosolic DNA sensing by cGAS

Çivril, F., Deimling, T., Mann, C. C. D. O., Ablasser, A., Moldt, M., Witte, G., Hornung, V., & Hopfner, K. (2013) · Nature · doi:10.1038/nature12305 · Cited by 888 · see citing works

Impaired response to interferon-α/β and lethal viral disease in human STAT1 deficiency

Boisson‐Dupuis, S., Jouanguy, E., Al-Hajjar, S. H., Fieschi, C., Al-Mohsen, I. Z., Aljumaah, S., Yang, K., Chapgier, A. L. A., Eidenschenk, C., Eid, P., et al. (2003) · Nature Genetics · doi:10.1038/ng1097 · Cited by 814 · see citing works

Systematic identification of type I and type II interferon-induced antiviral factors

Liu, S.-Y., Sanchez, D. J., Aliyari, R., Sun, L., & Cheng, G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114981109 · Cited by 446 · see citing works

Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus

Manicassamy, B., Manicassamy, S., Belicha‐Villanueva, A., Pisanelli, G., Pulendran, B., & García‐Sastre, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914994107 · Cited by 424 · see citing works

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

Kranzusch, P. J., Lee, A. S.-Y., Berger, J. M., & Doudna, J. A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.008 · Cited by 385 · see citing works

Newcastle Disease Virus (NDV)-Based Assay Demonstrates Interferon-Antagonist Activity for the NDV V Protein and the Nipah Virus V, W, and C Proteins

Park, M., Shaw, M. L., Muñoz‐Jordán, J. L., Cros, J. F., Nakaya, T., Bouvier, N. M., Palese, P., García‐Sastre, A., & Basler, C. F. (2002) · Journal of Virology · doi:10.1128/jvi.77.2.1501-1511.2003 · Cited by 376 · see citing works

Infection of Ciliated Cells by Human Parainfluenza Virus Type 3 in an In Vitro Model of Human Airway Epithelium

Zhang, L., Bukreyev, A., Thompson, C. I., Watson, B., Peeples, M. E., Collins, P. L., & Pickles, R. J. (2005) · Journal of Virology · doi:10.1128/jvi.79.2.1113-1124.2005 · Cited by 302 · see citing works

GENETIC AND PHENOTYPIC VARIATION OF WEST NILE VIRUS IN NEW YORK, 2000–2003

Ebel, G. D., CARRICABURU, J., Young, D. S., Bernard, K. A., & Kramer, L. D. (2004) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2004.71.493 · Cited by 250 · see citing works

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma

Hwang, S., Maloney, N. S., Bruinsma, M. W., Goel, G., Duan, E., Zhang, L., Shrestha, B., Diamond, M., Dani, A., Sosnovtsev, S. V., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.03.002 · Cited by 249 · see citing works

Identification and Characterization of Interferon-Induced Proteins That Inhibit Alphavirus Replication

Zhang, Y., Burke, C. W., Ryman, K. D., & Klimstra, W. B. (2007) · Journal of Virology · doi:10.1128/jvi.01282-07 · Cited by 241 · see citing works

IPS-1 Is Essential for the Control of West Nile Virus Infection and Immunity

Suthar, M. S., Ma, D. Y., Thomas, S., Lund, J. M., Zhang, N., Daffis, S., Rudensky, A. Y., Bevan, M. J., Clark, E. A., Murali‐Krishna, K., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000757 · Cited by 224 · see citing works

The Essential, Nonredundant Roles of RIG-I and MDA5 in Detecting and Controlling West Nile Virus Infection

Errett, J. S., Suthar, M. S., McMillan, A., Diamond, M., & Gale, M. (2013) · Journal of Virology · doi:10.1128/jvi.01488-13 · Cited by 201 · see citing works

Cell-Specific IRF-3 Responses Protect against West Nile Virus Infection by Interferon-Dependent and -Independent Mechanisms

Daffis, S., Samuel, M. A., Keller, B. C., Gale, M., & Diamond, M. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030106 · Cited by 194 · see citing works

Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro

Schoggins, J. W., Dorner, M., Feulner, M., Imanaka, N., Murphy, M. Y., Ploß, A., & Rice, C. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212379109 · Cited by 184 · see citing works

Cell Cycle Status Affects Coxsackievirus Replication, Persistence, and Reactivation In Vitro

Feuer, R., Mena, I., Pagarigan, R. R., Slifka, M. K., & Whitton, J. L. (2002) · Journal of Virology · doi:10.1128/jvi.76.9.4430-4440.2002 · Cited by 183 · see citing works

High-efficiency CAG-FLPe Deleter Mice in C57BL/6J Background

Kanki, H., SUZUKI, H., & Itohara, S. (2006) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.55.137 · Cited by 160 · see citing works

Recovery of human metapneumovirus from cDNA: optimization of growth in vitro and expression of additional genes

Biacchesi, S., Skiadopoulos, M. H., Tran, K. C., Murphy, B. R., Collins, P. L., & Buchholz, U. J. (2004) · Virology · doi:10.1016/j.virol.2003.12.020 · Cited by 147 · see citing works

Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication

Metz, P., Dazert, E., Ruggieri, A., Mazur, J., Kaderali, L., Kaul, A., Zeuge, U., Windisch, M. P., Trippler, M., Lohmann, V., et al. (2012) · Hepatology · doi:10.1002/hep.25908 · Cited by 143 · see citing works

A Vectored Measles Virus Induces Hepatitis B Surface Antigen Antibodies While Protecting Macaques against Measles Virus Challenge

Valle, J. R., Devaux, P., Hodge, G., Wegner, N. J., McChesney, M. B., & Cattaneo, R. (2007) · Journal of Virology · doi:10.1128/jvi.00923-07 · Cited by 87 · see citing works

Visualizing the Replication Cycle of Bunyamwera Orthobunyavirus Expressing Fluorescent Protein-Tagged Gc Glycoprotein

Shí, X., van Mierlo, J. T., French, A. S., & Elliott, R. M. (2010) · Journal of Virology · doi:10.1128/jvi.00902-10 · Cited by 78 · see citing works

Infection patterns of o’nyong nyong virus in the malaria‐transmitting mosquito, Anopheles gambiae

Brault, A. C., Foy, B. D., Myles, K. M., Kelly, C. L. H., Higgs, S., Weaver, S. C., Olson, K. E., Miller, B. R., & Powers, A. M. (2004) · Insect Molecular Biology · doi:10.1111/j.0962-1075.2004.00521.x · Cited by 76 · see citing works

Multiple Interferon Stimulated Genes Synergize with the Zinc Finger Antiviral Protein to Mediate Anti-Alphavirus Activity

Karki, S., Li, M. M. H., Schoggins, J. W., Tian, S., Rice, C. M., & MacDonald, M. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037398 · Cited by 70 · see citing works

A functional genomic screen reveals novel host genes that mediate interferon-alpha’s effects against hepatitis C virus

Zhao, H., Lin, W., Kumthip, K., Du, C., Fusco, D. N., Hofmann, O., Jilg, N., Tai, A. W., Goto, K., Zhang, L., et al. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.07.026 · Cited by 63 · see citing works

A Determinant of Sindbis Virus Neurovirulence Enables Efficient Disruption of Jak/STAT Signaling

Simmons, J. D., Wollish, A. C., & Heise, M. T. (2010) · Journal of Virology · doi:10.1128/jvi.00577-10 · Cited by 61 · see citing works

Inhibition of HIV-1 Particle Assembly by 2′,3′-Cyclic-Nucleotide 3′-Phosphodiesterase

Wilson, S. J., Schoggins, J. W., Zang, T. M., Kutluay, S. B., Jouvenet, N., Alim, M., Bitzegeio, J., Rice, C. M., & Bieniasz, P. D. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.08.012 · Cited by 58 · see citing works

C7L Family of Poxvirus Host Range Genes Inhibits Antiviral Activities Induced by Type I Interferons and Interferon Regulatory Factor 1

Meng, X., Schoggins, J. W., Rose, L. F., Cao, J., Ploß, A., Rice, C. M., & Xiang, Y. (2012) · Journal of Virology · doi:10.1128/jvi.06140-11 · Cited by 49 · see citing works

A Genetic Screen Identifies Interferon-α Effector Genes Required to Suppress Hepatitis C Virus Replication

Fusco, D. N., Brisac, C., John, S. P., Huang, Y., Chin, C. R., Xie, T., Zhao, H., Jilg, N., Zhang, L., Chevaliez, S., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.026 · Cited by 42 · see citing works

Viable Polioviruses That Encode 2A Proteins with Fluorescent Protein Tags

Teterina, N. L., Levenson, E. A., & Ehrenfeld, E. (2009) · Journal of Virology · doi:10.1128/jvi.01578-09 · Cited by 38 · see citing works

An infectious recombinant equine arteritis virus expressing green fluorescent protein from its replicase gene

van den Born, E., Posthuma, C. C., Knoops, K., & Snijder, E. J. (2007) · Journal of General Virology · doi:10.1099/vir.0.82590-0 · Cited by 27 · see citing works

Interferon-stimulated genes: A complex web of host defenses

Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067 · see citing works

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333 · see citing works

Molecular mechanisms and cellular functions of cGAS–STING signalling

Hopfner, K.-P., & Hornung, V. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0244-x · Cited by 2,052 · see citing works

cGAS surveillance of micronuclei links genome instability to innate immunity

Mackenzie, K. J., Carroll, P., Martin, C.-A., Murina, O., Fluteau, A., Simpson, D. J., Olova, N., Sutcliffe, H., Rainger, J. K., Leitch, A., et al. (2017) · Nature · doi:10.1038/nature23449 · Cited by 1,752 · see citing works

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Karki, R., Sharma, B. R., Tuladhar, S., Williams, E. P., Zalduondo, L., Samir, P., Zheng, M., Sundaram, B., Banoth, B., Malireddi, R. K. S., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.025 · Cited by 1,734 · see citing works

STING: infection, inflammation and cancer.

Barber, G. N. (2015) · Nature Reviews Immunology · doi:10.1038/nri3921 · Cited by 1,313 · see citing works

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

Kwon, J., & Bakhoum, S. F. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0761 · Cited by 1,293 · see citing works

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

Wu, J., & Chen, Z. J. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120156 · Cited by 1,179 · see citing works

Mitochondrial DNA in innate immune responses and inflammatory pathology

West, A. P., & Shadel, G. S. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.21 · Cited by 1,115 · see citing works

cGAS in action: Expanding roles in immunity and inflammation

Ablasser, A., & Chen, Z. J. (2019) · Science · doi:10.1126/science.aat8657 · Cited by 1,077 · see citing works

Innate immunity to influenza virus infection

Iwasaki, A., & Pillai, P. S. (2014) · Nature reviews. Immunology · doi:10.1038/nri3665 · Cited by 1,064 · see citing works

Interferon-Stimulated Genes: What Do They All Do?

Schoggins, J. W. (2019) · Annual Review of Virology · doi:10.1146/annurev-virology-092818-015756 · Cited by 1,036 · see citing works

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

Cai, X., Chiu, Y., & Chen, Z. J. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.040 · Cited by 995 · see citing works

A Mouse Model of Zika Virus Pathogenesis

Lazear, H. M., Govero, J., Smith, A. M., Platt, D. J., Fernandez, E., Miner, J. J., & Diamond, M. S. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.03.010 · Cited by 909 · see citing works

Mitochondrial DNA in inflammation and immunity

Riley, J. S., & Tait, S. W. G. (2020) · EMBO Reports · doi:10.15252/embr.201949799 · Cited by 876 · see citing works

Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway

Zhang, X., Bai, X., & Chen, Z. J. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.013 · Cited by 845 · see citing works

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

Gao, D., Li, T., Li, X.-D., Chen, X., Li, Q., Wight‐Carter, M., & Chen, Z. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516465112 · Cited by 685 · see citing works

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

Watson, R. O., Bell, S. L., MacDuff, D. A., Kimmey, J. M., Diner, E. J., Olivas, J., Vance, R. E., Stallings, C. L., Virgin, H. W., & Cox, J. S. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.05.004 · Cited by 645 · see citing works

Innate immunity: the first line of defense against SARS-CoV-2

Diamond, M., & Kanneganti, T. (2022) · Nature Immunology · doi:10.1038/s41590-021-01091-0 · Cited by 612 · see citing works

Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)

Lächelt, U., & Wagner, E. (2015) · Chemical Reviews · doi:10.1021/cr5006793 · Cited by 600 · see citing works

STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3

Li, N., Zhou, H., Wu, H., Wu, Q., Duan, M., Deng, W., & Tang, Q. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101215 · Cited by 595 · see citing works

IRF3 and type I interferons fuel a fatal response to myocardial infarction

King, K. R., Aguirre, A. D., Ye, Y., Sun, Y., Roh, J. D., Ng, R. P., Köhler, R. H., Arlauckas, S. P., Iwamoto, Y., Savol, A. J., et al. (2017) · Nature Medicine · doi:10.1038/nm.4428 · Cited by 571 · see citing works

Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

Prabakaran, T., Bodda, C., Krapp, C., Zhang, B., Christensen, M. H., Sun, C., Reinert, L. S., Cai, Y., Jensen, S. B., Skouboe, M. K., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201797858 · Cited by 478 · see citing works

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

Utay, N. S., Bosinger, S. E., Estes, J. D., Zhu, R. T., Tharp, G. K., Boritz, E., Levin, D., Wijeyesinghe, S., Nganou‐Makamdop, K., Prete, G. Q. D., et al. (2014) · Nature · doi:10.1038/nature13554 · Cited by 458 · see citing works

Viral evasion of intracellular DNA and RNA sensing

Chan, Y., & Gack, M. U. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.45 · Cited by 451 · see citing works

Interplay between SARS-CoV-2 and the type I interferon response

Sa Ribero, M., Jouvenet, N., Dreux, M., & Nisole, S. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008737 · Cited by 443 · see citing works

The cGAS-STING Defense Pathway and Its Counteraction by Viruses

Ma, Z., & Damania, B. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.01.010 · Cited by 442 · see citing works

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

Tan, J. X., Sun, L., Chen, J., & Chen, Z. J. (2018) · Annual Review of Microbiology · doi:10.1146/annurev-micro-102215-095605 · Cited by 437 · see citing works

Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6

Tyrrell, D. J., & Goldstein, D. R. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0431-7 · Cited by 434 · see citing works

RIG-I in RNA virus recognition

Kell, A. M., & Gale, M. (2015) · Virology · doi:10.1016/j.virol.2015.02.017 · Cited by 424 · see citing works

Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy

Li, A., Yi, M., Qin, S., Song, Y., Chu, Q., & Wu, K. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0721-x · Cited by 413 · see citing works

Interferons and viruses: an evolutionary arms race of molecular interactions

Hoffmann, H.-H., Schneider, W. M., & Rice, C. M. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.01.004 · Cited by 408 · see citing works

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

Zierhut, C., Yamaguchi, N., Paredes, M. C. G., Luo, J., Carroll, T., & Funabiki, H. (2019) · Cell · doi:10.1016/j.cell.2019.05.035 · Cited by 403 · see citing works

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

Wassermann, R., Gulen, M. F., Sala, C., Perin, S. G., Lou, Y., Rybniker, J., Schmid-Burgk, J. L., Schmidt, T., Hornung, V., Cole, S. T., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.05.003 · Cited by 401 · see citing works

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

Aguirre, S., Luthra, P., Sánchez-Aparicio, M. T., Maestre, A. M., Patel, J. R., Lamothe, F., Fredericks, A. C., Tripathi, S., Zhu, T., Silva, J. P., et al. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.37 · Cited by 393 · see citing works

Resurrection of endogenous retroviruses during aging reinforces senescence

Liu, X., Liu, Z., Wu, Z., Ren, J., Fan, Y., Sun, L., Cao, G., Niu, Y., Zhang, B., Ji, Q., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.017 · Cited by 390 · see citing works

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome

Gray, E. E., Treuting, P. M., Woodward, J. J., & Stetson, D. B. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500969 · Cited by 384 · see citing works

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

Collins, A. C., Cai, H., Li, T., Franco, L. H., Li, X.-D., Nair, V. R., Scharn, C. R., Stamm, C. E., Levine, B., Chen, Z. J., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.05.005 · Cited by 384 · see citing works

TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses

Chen, M., Meng, Q., Qin, Y., Liang, P., Tan, P., He, L., Zhou, Y., Chen, Y., Huang, J., Wang, R., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.08.025 · Cited by 367 · see citing works

Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways

Zevini, A., Olagnier, D. P., & Hiscott, J. B. (2017) · Trends in Immunology · doi:10.1016/j.it.2016.12.004 · Cited by 364 · see citing works

Constitutive immune mechanisms: mediators of host defence and immune regulation

Paludan, S. R., Pradeu, T., Masters, S. L., & Mogensen, T. H. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0391-5 · Cited by 363 · see citing works

Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection

Yockey, L. J., Varela, L., Rakib, T., Khoury-Hanold, W., Fink, S. L., Stutz, B., Szigeti‐Buck, K., van den Pol, A. N., Lindenbach, B. D., Horváth, T. L., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.004 · Cited by 358 · see citing works

Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism

Ouimet, M. I., Köster, S., Sakowski, E. T., Ramkhelawon, B., Solingen, C. V., Oldebeken, S. R., Karunakaran, D., Portal‐Celhay, C., Sheedy, F. J., Ray, T. D., et al. (2016) · Nature Immunology · doi:10.1038/ni.3434 · Cited by 357 · see citing works

The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis

Erttmann, S. F., Swacha, P., Aung, K. M., Brindefalk, B., Jiang, H., Härtlová, A., Uhlin, B. E., Wai, S. N., & Gekara, N. O. (2022) · Immunity · doi:10.1016/j.immuni.2022.04.006 · Cited by 353 · see citing works

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

Hornung, V., Hartmann, R., Ablasser, A., & Hopfner, K. (2014) · Nature reviews. Immunology · doi:10.1038/nri3719 · Cited by 341 · see citing works

Biochemistry and Molecular Biology of Flaviviruses

Barrows, N. J., Campos, R. K., Liao, K., Prasanth, K. R., Soto-Acosta, R., Yeh, S.-C., Schott, G., Pompon, J., Sessions, O. M., Bradrick, S. S., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00719 · Cited by 339 · see citing works

Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

Zheng, J., Mo, J., Zhu, T., Zhuo, W., Yi, Y., Hu, S., Yin, J., Zhang, W., Zhou, H., & Liu, Z. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01250-1 · Cited by 332 · see citing works

Orthobunyaviruses: recent genetic and structural insights

Elliott, R. M. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3332 · Cited by 330 · see citing works

Transmission of innate immune signaling by packaging of cGAMP in viral particles

Gentili, M., Kowal, J., Tkach, M., Satoh, T., Lahaye, X., Conrad, C., Boyron, M., Lombard, B., Durand, S., Kroemer, G., et al. (2015) · Science · doi:10.1126/science.aab3628 · Cited by 322 · see citing works

Mitochondria, Oxidative Stress and Innate Immunity

Chen, Y., Zhou, Z., & Min, W. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01487 · Cited by 315 · see citing works

Interferon-stimulated genes: roles in viral pathogenesis

Schoggins, J. W. (2014) · Current Opinion in Virology · doi:10.1016/j.coviro.2014.03.006 · Cited by 315 · see citing works

Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling

Xu, M. M., Yang, P., Han, D., Shi, Y., Cao, X., Liang, H. L., Chen, X., Li, X.-D., Deng, L., Chen, Z. J., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.016 · Cited by 315 · see citing works

cGAS is activated by DNA in a length‐dependent manner

Luecke, S., Holleufer, A., Christensen, M. H., Jønsson, K. L., Boni, G. A., Sørensen, L. K., Johannsen, M., Jakobsen, M. R., Hartmann, R., & Paludan, S. R. (2017) · EMBO Reports · doi:10.15252/embr.201744017 · Cited by 308 · see citing works

STING–IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity

Mao, Y., Luo, W., Zhang, L., Wu, W., Yuan, L., Xu, H. Y., Song, J., Fujiwara, K., Abe, J., LeMaire, S. A., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309017 · Cited by 307 · see citing works

Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses

Feng, H., Zhang, Y.-B., Gui, J., Lemon, S. M., & Yamane, D. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009220 · Cited by 293 · see citing works

Cytoplasmic DNA: sources, sensing, and role in aging and disease

Miller, K. N., Victorelli, S. G., Salmonowicz, H., Dasgupta, N., Liu, T., Passos, J. F., & Adams, P. D. (2021) · Cell · doi:10.1016/j.cell.2021.09.034 · Cited by 288 · see citing works

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

Kerur, N., Fukuda, S., Banerjee, D., Kim, Y., Fu, D., Apicella, I., Varshney, A., Yasuma, R., Fowler, B. J., Baghdasaryan, E., et al. (2017) · Nature Medicine · doi:10.1038/nm.4450 · Cited by 285 · see citing works

The Commensal Microbiota and Viral Infection: A Comprehensive Review

Li, N., Ma, W., Pang, M., Fan, Q., & Hua, J.-L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01551 · Cited by 282 · see citing works

HIV-1 and interferons: who's interfering with whom?

Doyle, T., Goujon, C., & Malim, M. H. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3449 · Cited by 280 · see citing works

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

Jønsson, K. L., Laustsen, A., Krapp, C., Skipper, K. A., Thavachelvam, K., Hotter, D., Egedal, J. H., Kjølby, M., Mohammadi, P., Prabakaran, T., et al. (2017) · Nature Communications · doi:10.1038/ncomms14391 · Cited by 279 · see citing works

A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion

Xia, P., Wang, S., Ye, B., Du, Y., Li, C., Xiong, Z., Qu, Y., & Fan, Z. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.016 · Cited by 279 · see citing works

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

Neufeldt, C. J., Cerikan, B., Cortese, M., Frankish, J., Lee, J., Płóciennikowska, A., Heigwer, F., Prasad, V. R., Joecks, S., Burkart, S. S., et al. (2022) · Communications Biology · doi:10.1038/s42003-021-02983-5 · Cited by 279 · see citing works

Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein

Wu, J., Li, W., Shao, Y., Avey, D. R., Fu, B., Gillen, J., Hand, T. H., Ma, S., Liu, X., Miley, W., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.07.015 · Cited by 278 · see citing works

Alveolar macrophage–derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes

Goritzka, M., Makris, S., Kausar, F., Durant, L. R., Pereira, C., Kumagai, Y., Culley, F. J., Mack, M., Akira, S., & Johansson, C. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20140825 · Cited by 277 · see citing works

Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury

Cao, D. J., Schiattarella, G. G., Villalobos, E., Jiang, N., May, H. I., Li, T., Chen, Z. J., Gillette, T. G., & Hill, J. A. (2018) · Circulation · doi:10.1161/circulationaha.117.031046 · Cited by 272 · see citing works

Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response

Wan, D., Jiang, W., & Hao, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00615 · Cited by 270 · see citing works

Antiviral Activity of Human OASL Protein Is Mediated by Enhancing Signaling of the RIG-I RNA Sensor

Zhu, J., Zhang, Y., Ghosh, A., Cuevas, R. A., Forero, A., Dhar, J., Ibsen, M. S., Schmid-Burgk, J. L., Schmidt, T., Ganapathiraju, M. K., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.007 · Cited by 269 · see citing works

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA

Barnett, K. C., Coronas-Serna, J. M., Zhou, W., Ernandes, M. J., Cao, A., Kranzusch, P. J., & Kagan, J. C. (2019) · Cell · doi:10.1016/j.cell.2019.01.049 · Cited by 268 · see citing works

cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection

Orzalli, M. H., Broekema, N. M., Diner, B. A., Hancks, D. C., Elde, N. C., Cristea, I. M., & Knipe, D. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424637112 · Cited by 264 · see citing works

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis

Dey, B., Dey, R. J., Cheung, L. S., Pokkali, S., Guo, H., Lee, J., & Bishai, W. R. (2015) · Nature Medicine · doi:10.1038/nm.3813 · Cited by 263 · see citing works

Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death

Jiang, H., Xue, X., Panda, S., Kawale, A. S., Hooy, R. M., Liang, F., Sohn, J., Sung, P., & Gekara, N. O. (2019) · The EMBO Journal · doi:10.15252/embj.2019102718 · Cited by 263 · see citing works

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

Naujoks, J., Tabeling, C., Dill, B. D., Hoffmann, C., Brown, A. S., Kunze, M., Kempa, S., Peter, A., Mollenkopf, H.-J., Dorhoi, A., et al. (2016) · PLOS Pathogens · doi:10.1371/journal.ppat.1005408 · Cited by 261 · see citing works

Cyclic GMP–AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

Kato, K., Omura, H., Ishitani, R., & Nureki, O. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-044813 · Cited by 260 · see citing works

STING controls nociception via type I interferon signalling in sensory neurons

Donnelly, C. R., Jiang, C., Andriessen, A. S., Wang, K., Wang, Z., Ding, H., Zhao, J., Luo, X., Lee, M. S., Lei, Y. L., et al. (2021) · Nature · doi:10.1038/s41586-020-03151-1 · Cited by 254 · see citing works

Viruses transfer the antiviral second messenger cGAMP between cells

Bridgeman, A., Maelfait, J., Davenne, T., Partridge, T., Peng, Y., Mayer, A., Dong, T., Kaever, V., Borrow, P., & Rehwinkel, J. (2015) · Science · doi:10.1126/science.aab3632 · Cited by 253 · see citing works

STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment

Ohkuri, T., Ghosh, A., Kosaka, A., Zhu, J., Ikeura, M., David, M., Watkins, S. C., Sarkar, S. N., & Okada, H. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0099 · Cited by 252 · see citing works

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling

Kranzusch, P. J., Wilson, S. C., Lee, A. S. Y., Berger, J. M., Doudna, J. A., & Vance, R. E. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.022 · Cited by 250 · see citing works

Identification of Interferon-Stimulated Genes with Antiretroviral Activity

Kane, M., Zang, T. M., Rihn, S. J., Zhang, F., Kueck, T., Alim, M., Schoggins, J. W., Rice, C. M., Wilson, S. J., & Bieniasz, P. D. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.08.005 · Cited by 250 · see citing works

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

Gentili, M., Lahaye, X., Nadalin, F., Nader, G. P. F., Lombardi, E. P., Hervé, S., Silva, N. S. D., Rookhuizen, D. C., Zueva, E., Goudot, C., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.105 · Cited by 248 · see citing works

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

Zang, R., Case, J. B., Yutuc, E., Ma, X., Shen, S., Gomez Castro, M. F., Liu, Z., Zeng, Q., Zhao, H., Son, J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2012197117 · Cited by 240 · see citing works

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling

Eaglesham, J. B., Pan, Y., Kupper, T. S., & Kranzusch, P. J. (2019) · Nature · doi:10.1038/s41586-019-0928-6 · Cited by 238 · see citing works

Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses

Moriyama, M., Koshiba, T., & Ichinohe, T. (2019) · Nature Communications · doi:10.1038/s41467-019-12632-5 · Cited by 234 · see citing works

Negative regulation of the interferon response by an interferon-induced long non-coding RNA

Kambara, H., Niazi, F., Kostadinova, L., Moonka, D., Siegel, C., Post, A. B., Carnero, E., Barriocanal, M., Fortes, P., Anthony, D. D., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku713 · Cited by 230 · see citing works

A prenylated dsRNA sensor protects against severe COVID-19

Wickenhagen, A., Sugrue, E., Lytras, S., Srikeerthana, K., Noerenberg, M., Turnbull, M. L., Loney, C., Herder, V., Allan, J., Jarmson, I., et al. (2021) · Science · doi:10.1126/science.abj3624 · Cited by 227 · see citing works

Dengue virus activates cGAS through the release of mitochondrial DNA

Sun, B., Sundström, K. B., Chew, J. J., Bist, P., Gan, E. S., Tan, H. C., Goh, K. C., Chawla, T., Tang, C. K., & Ooi, E. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-03932-1 · Cited by 225 · see citing works

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

Xia, P., Ye, B., Wang, S., Zhu, X., Du, Y., Xiong, Z., Tian, Y., & Fan, Z. (2016) · Nature Immunology · doi:10.1038/ni.3356 · Cited by 220 · see citing works

Innate immune recognition of DNA: A recent history

Dempsey, A., & Bowie, A. (2015) · Virology · doi:10.1016/j.virol.2015.03.013 · Cited by 216 · see citing works

Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1‐caspase‐1 axis

Zheng, Y., Liu, Q., Wu, Y., Ma, L., Zhang, Z., Liu, T., Jin, S., She, Y., Li, Y., & Cui, J. (2018) · The EMBO Journal · doi:10.15252/embj.201899347 · Cited by 212 · see citing works

The interactions between cGAS-STING pathway and pathogens

Cheng, Z., Dai, T., He, X., Zhang, Z., Xie, F., Wang, S., Zhang, L., & Zhou, F. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0198-7 · Cited by 212 · see citing works

Functional landscape of SARS-CoV-2 cellular restriction

Martin‐Sancho, L., Lewinski, M. K., Pache, L., Stoneham, C. A., Yin, X., Becker, M. E., Pratt, D. R., Churas, C., Rosenthal, S. B., Liu, S. N., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.04.008 · Cited by 210 · see citing works

Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation

Xie, W., Lama, L., Adura, C., Tomita, D., Glickman, J. F., Tuschl, T., & Patel, D. J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1905013116 · Cited by 209 · see citing works

SARS-CoV-2 biology and host interactions

Steiner, S., Kratzel, A., Barut, G. T., Lang, R. M., Moreira, É. A., Thomann, L., Kelly, J. N., & Thiel, V. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-023-01003-z · Cited by 208 · see citing works

Role of the cGAS–STING pathway in cancer development and oncotherapeutic approaches

Khoo, L. T., & Chen, L. (2018) · The EMBO Reports · doi:10.15252/embr.201846935 · Cited by 204 · see citing works

STING-associated vasculopathy develops independently of IRF3 in mice

Warner, J. D., Irizarry-Caro, R. A., Bennion, B. G., Ai, T. L., Smith, A. M., Miner, C. A., Sakai, T., Gonugunta, V. K., Wu, J., Platt, D. J., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20171351 · Cited by 204 · see citing works

Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer

Corrales, L. P., & Gajewski, T. F. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1362 · Cited by 202 · see citing works

PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1

Yoh, S. M., Schneider, M., Seifried, J., Soonthornvacharin, S., Akleh, R. E., Olivieri, K. C., Jesus, P. D. D., Ruan, C., de Castro, E., Ruiz, P. A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.050 · Cited by 200 · see citing works

Mitochondrial dysfunction as a trigger of innate immune responses and inflammation

West, A. P. (2017) · Toxicology · doi:10.1016/j.tox.2017.07.016 · Cited by 199 · see citing works

The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications

Shen, M., Jiang, X., Qiu, P., Oyang, L., Ren, Z., Wang, J., Peng, M., Zhou, Y., Deng, X., & Liao, Q. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01691-5 · Cited by 197 · see citing works

Modeling rotavirus infection and antiviral therapy using primary intestinal organoids

Yin, Y., Bijvelds, M. J. C., Dang, W., Xu, L., van der Eijk, A. A., Knipping, K., Tüysüz, N., Dekkers, J. F., Wang, Y., de Jonge, J., et al. (2015) · Antiviral Research · doi:10.1016/j.antiviral.2015.09.010 · Cited by 196 · see citing works

Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication

Zhang, J., Zhao, J., Xu, S., Li, J., He, S., Zeng, Y. A., Xie, L., Xie, N., Liu, T., Lee, K., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.07.004 · Cited by 196 · see citing works

Cyclic guanosine monophosphate/adenosine monophosphate synthase (cGAS), innate immune responses, and viral hepatitis

Verrier, E. R., Gack, M. U., Baumert, T. F., Schoggins, J. W., MacDuff, D. A., Imanaka, N., Gainey, M. D., Shrestha, B., & Eitson, J. L. (2014) · Hepatology · doi:10.1002/hep.27187 · Cited by 2 · see citing works

Innate Immune Priming by cGAS as a Preparatory Countermeasure Against RNA Virus InfectionPreprint

Parker, M. T., Gopinath, S., Perez, C. E., Linehan, M. M., Crawford, J. M., Iwasaki, A., & Lindenbach, B. D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/434027 · Cited by 6 · see citing works

Finding a needle in a haystack of needles – a productive hunt for interferon stimulated genes with antiviral activity

Franz, K. M., & Kagan, J. C. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2013.108 · Cited by 2 · see citing works

Induction and activation of cGAS DNA sensor by Sindbis virus

Fung, S. (2017) · doi:10.5353/th_991043982883203414

I04 Identification and characterization of antiviral interferon effectors across the viral phylogeny

Schoggins, J. W. (2012) · Cytokine · doi:10.1016/j.cyto.2012.06.294