The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design
Open accessAbstract
Traditionally, vaccines have been developed by cultivating infectious agents and isolating the inactivated whole pathogen or some of its purified components. 20 years ago, reverse vaccinology enabled vaccine discovery and design based on information deriving from the sequence of microbial genomes rather than via the growth of pathogens. Today, the high throughput discovery of protective human antibodies, sequencing of the B cell repertoire, and the increasing structural characterization of protective antigens and epitopes provide the molecular and mechanistic understanding to drive the discovery of novel vaccines that were previously impossible. We are entering a “reverse vaccinology 2.0” era.
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Cites
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Immunoinformatics and Vaccine Development: An Overview
Oli, A. N., Obialor, W. O., Ifeanyichukwu, M. O., Odimegwu, D. C., Okoyeh, J. N., Emechebe, G. O., Adejumo, S. A., & Ibeanu, G. C. (2020) · ImmunoTargets and Therapy · doi:10.2147/itt.s241064 · Cited by 281
Structure-Based Vaccine Antigen Design
Graham, B. S., Gilman, M. S. A., & McLellan, J. S. (2019) · Annual Review of Medicine · doi:10.1146/annurev-med-121217-094234 · Cited by 234
De novo protein design enables the precise induction of RSV-neutralizing antibodies
Sesterhenn, F., Yang, C., Bonet, J., Cramer, J. T., Wen, X., Wang, Y., Chiang, C.-I., Abriata, L. A., Kucharska, I., Castoro, G., et al. (2020) · Science · doi:10.1126/science.aay5051 · Cited by 191
Yin, R., & Pierce, B. G. (2024) · Protein Science · doi:10.1002/pro.4865 · Cited by 145
Metadata
- Authors
- Rappuoli, R., Bottomley, M. J., D’Oro, U., Finco, O., & De Gregorio, E.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2016-03-28
- Volume
- 213
- Issue
- 4
- Pages
- 469-481
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2323929490
- Cited by
- 435
- References
- 95
- FWCI
- 17.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Rappuoli, R., Bottomley, M. J., D’Oro, U., Finco, O., & De Gregorio, E. (2016). Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20151960
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
