Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice
Guo, Jing L., Narasimhan, Sneha, Changolkar, Lakshmi, He, Zhuohao, Stieber, Anna, Zhang, Bin, Gathagan, Ronald J., Iba, Michiyo, McBride, Jennifer D., Trojanowski, John Q., Lee, Virginia M.Y.·2016·Journal of Experimental Medicine
Cited by (441)
Items 301–400 of 441
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- Advancing Alzheimer’s research by improving disease modeling of secondary tauopathyEthan R. Roy, Wei Cao · 2025 · npj Dementia
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- Illuminating the Structural Basis of Tau Aggregation by Intramolecular Distance Tracking: A Perspective on MethodsZhikai Zeng, Yann Fichou, Michael P. Vigers, Karen Tsay, Songi Han · 2022 · The Journal of Physical Chemistry B
- Identification of small molecules and related targets that modulate tau pathology in a seeded primary neuron modelGarrett S. Gibbons, Hailey Gould, Virginia M.‐Y. Lee, Alex Crowe, Kurt R. Brunden · 2023 · Journal of Biological Chemistry
- Tau from SPAM Transgenic Mice Exhibit Potent Strain-Specific Prion-Like Seeding Properties Characteristic of Human Neurodegenerative DiseasesEthan D. Smith, Giavanna Paterno, Brach M. Bell, Kimberly-Marie M. Gorion, Stefan Prokop, Benoit I. Giasson · 2025 · NeuroMolecular Medicine
- Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seedsMarta Pérez-Rando, Simon Dujardin, Rachel E. Bennett, Caitlin Commins, Tara J. Nibhanupudy, Bradley T. Hyman · 2020 · Acta Neuropathologica Communications
- A short peptide from sAPPα binding to BACE1-APP action site rescues Alzheimer-like pathologyXia Lai, Jie Hu, He Liu, Ling Lan, Yan Long, Xia Gao, Juan Deng · 2021 · Neuroscience Letters
- TauopathyHao Chi, Tzu‐Kang Sang, Hui-Yun Chang · 2019 · IntechOpen eBooks
- Joint Computational/Cell-Based Approach for Screening Inhibitors of Tau Oligomerization: A Proof-of-Concept StudyViet Hoang Man, Da Lin, Xibing He, Jie Gao, Junmei Wang · 2022 · Journal of Alzheimer s Disease
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- Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing miceSuzanne Lam, Anne‐Sophie Hérard, Susana Boluda, Fanny Petit, Sabiha Eddarkaoui, Karine Cambon, The Brainbank Neuro-CEB Neuropathology Network, Jean‐Luc Picq, Luc Buée, Charles J. Duyckaerts et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Size-dependent secondary nucleation and amplification of α-synuclein amyloid fibrilsArunima Sakunthala, Debalina Datta, Ambuja Navalkar, Laxmikant G. Gadhe, Pradeep Kadu, Komal Patel, Surabhi Mehra, Rakesh Kumar, Debdeep Chatterjee, Kundan Sengupta et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Development of a robust, physiologically relevant neuronal tau aggregation assay for tau-related drug discoveryJessica Wu, Katherine Titterton, Rebecca M. Sebastian, Nandini Romanul, Kiran Yanamandra, Bryan Mastis, Rui Chang, Saurabh Khasnavis, Taekyung Kwon, Yating Chai et al. · 2025 · Journal of Biological Chemistry
- In Vitro and In Vivo Evaluation of Small-Molecule Disassemblers of Pathological Tau FibrilsHope Pan, Xinyi Cheng, Jeffrey Zhang, Ke Hou, Kevin A. Murray, Kapil Manglani, Cansheng Zhu, Hung‐Kai Hsu, Marisa Mekkittikul, Tyler Halladay et al. · 2026 · ACS Chemical Neuroscience
- ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegenerationNaemeh Pourshafie, Desi C. Alexander, Hong Wei Xu, Kechun Yang, Greg Donahue, Xue Lei, Shuo Zhang, Oksana Shcherbakova, Connor Hogan, Michael Gilbert et al. · 2026 · Proceedings of the National Academy of Sciences
- Multiomic single nuclei profiling the mouse hippocampus reveals that ACSS2 confers neuronal resilience to tauopathyGabor Egervári, Desi C. Alexander, Hua Huang, Greg Donahue, Connor Hogan, Mariel R. Mendoza, Hong Wei Xu, Virginia Lee, Benjamin A. Garcia, Nancy M. Bonini et al. · 2026 · Alzheimer s & Dementia
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- Impact of Sterilization Methods on the Seeding Ability of Human Tau Proteopathic SeedsAnaliese R. Fernandes, Simon Dujardin, Anastasie Maté de Gérando, Bradley T. Hyman, Matthew P. Frosch · 2021 · Journal of Neuropathology & Experimental Neurology
- Does proteopathic tau propagate trans-synaptically in the brain?Wen Hui Hu, Fei Liu, Cheng‐Xin Gong, Khalid Iqbal · 2022 · Molecular Neurodegeneration
- Seeding-competent early tau multimers are associated with cell type-specific transcriptional signaturesRahel Feleke, Simona Jogaudaite, Elisavet Velentza‐Almpani, Leung Yeung-Yeung, Daniel Clode, Jeong Hun Ko, Ben Shin, Stephen Matthews, Maria Otero‐Jimenez, Marcelina J. Wojewska et al. · 2025 · Acta Neuropathologica
- Phosphorylation at serine 214 correlates with tau seeding activity in an age-dependent manner in two mouse models for tauopathies and is required for tau transsynaptic propagationPablo Martínez, Nur Jury, Henika Patel, Yanwen You, Abigail Perkins, Yingjian You, Audrey Lee‐Gosselin, Rubén Vidal, Cristian A. Lasagna‐Reeves · 2025 · Journal of Alzheimer s Disease
- Tau Pathology in Neurodegenerative DiseasesThomas Vogels, Tomáš Hromádka · 2021 · Neuromethods
- Astrocyte-secreted glypican-4 drives APOE4-dependent tau pathologySivaprakasam R. Saroja, Kirill Gorbachev, Julia TCW, Alison Goate, Ana C. Pereira · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Soluble Brain Homogenates from Diverse Human and Mouse Sources Preferentially Seed Diffuse Aβ Plaque Pathology When Injected into Newborn Mouse HostsBrenda D. Moore, Yona Levites, Guilian M. Xu, Hailey Hampton, Munir F Adamo, Cara L. Croft, Hunter S. Futch, Corey Moran, Susan Fromholt, Christopher Janus et al. · 2021 · Research Square
- Repositioning of polyubiquitin alters the pathologic tau filament structureRyohei Watanabe, Benjamin C. Creekmore, Nabil F. Darwich, Courtney L. Smith, Hong Xu, Angelina Baltazar, Sacha P. Salphati, Lakshmi N. Changolkar, Kevt’her Hoxha, Bin Zhang et al. · 2026 · Nature Structural & Molecular Biology
- Residue-Specific Modulation of Aggregation-Associated Interactions by Spermine in Tau, α-Synuclein, and Aβ40Saha, Debasis, Sun, Xun, Yang, Wangfei, Luo, Jinghui, Zheng, Wenwei · 2026 · JACS Au
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- Oral semaglutide vs DPP-4 inhibitors in reducing risk of cognitive impairment in elderly patients with HFpEF and obesityGiuseppe Armentaro, Cristiana Vitale, Velia Cassano, Marilisa Panza, Ilaria Gareri, Maria Mirabelli, Elena Succurro, Francesco Andreozzi, Antonio Brunetti, Gianluigi Savarese et al. · 2026 · Internal and Emergency Medicine
- Prion-like transmission of human tau strains in the mouse brainSofia Lövestam, Aki Shimozawa, Airi Tarutani, Reiko Ohtani, Masami Masuda‐Suzukake, Kazuko Hasegawa, Andrew Robinson, Yuko Saito, Shigeo Murayama, Mari Yoshida et al. · 2026 · Nature
- A tribute to John Q. Trojanowski (1946–2022), neuropathologist extraordinaireMichel Goedert, Maria Grazia Spillantini · 2022 · Brain Pathology
- In situ seeding assay: A novel technique for direct tissue localization of bioactive tauRomain Perbet, Anastasie Maté de Gérando, Calina A. Glynn, Cameron Donahue, Angelica Gaona, Raquel N. Taddei, Teresa Gómez‐Isla, Aurélien Lathuilière, Bradley T. Hyman · 2024 · Journal of Neuropathology & Experimental Neurology
- Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau SpreadElliot Jang, Kevt’her Hoxha, Damian Mozier, Abigail Insana, Ethan Farber, Lakshmi N. Changolkar, Bin Zhang, Tak Ian Chio, Alex Crowe, Richard J. Chen et al. · 2024 · Journal of Neuroscience
- LRP1-mediated p-tau propagation contributes to cognitive impairment after chronic neuropathic pain in ratsYouzhi Ning, Yue Zhang, Tao Jiang, Jianguo Feng, Jian Zhan, Cehua Ou, Lu Wang · 2024 · Neuroscience Research
- Distinct neuronal vulnerability and metabolic dysfunctions are characteristic features of fast-progressing Alzheimer's patients with Lewy bodiesMohammed Rahman, Preeti Sharma, Trisha Chattopadhyay, Sivaprakasam R. Saroja · 2025 · Journal of Biological Chemistry
- Beyond prion‐like spreading in neurodegenerative diseaseGeorg Meisl, James Benedict Rowe, David Klenerman · 2025 · Alzheimer s & Dementia
- Seeding Alzheimer’s disease-associated tau pathology in MAPT knock-in primary neurons causes early axonopathy and synaptic dysfunctionRebecca L. Mueller, Benjamin Combs, Nicholas M. Kanaan · 2025 · Scientific Reports
- Neurodegeneration and the Ordered Assembly of TauMichel Goedert · 2018 · Elsevier eBooks
- Frontotemporal lobar degenerationBoram Kim, Ashley Viera-Ortiz, Jessica M. Phan, David John Irwin, Edward B. Lee · 2022 · Elsevier eBooks
- In Vitro Amplification of Pathogenic Tau Seeds from Neurodegenerative Disease Patient BrainsHong Wei Xu, Virginia M. -Y. Lee · 2022 · Methods in molecular biology
- A Human Neuron/Astrocyte Co‐culture to Model Seeded and Spontaneous Intraneuronal Tau AggregationKevin Llewelyn Batenburg, Susan Karijn Rohde, Paulien Cornelissen‐Steijger, Nicole Breeuwsma, Vivi Majella Heine, Wiep Scheper · 2023 · Current Protocols
- Exploring temporal and sex-linked dysregulation in Alzheimer disease phosphoproteomeSerhan Yılmaz, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Rihua Wang, Xin Qi, Mehmet Koyutürk, Mark R. Chance · 2024 · iScience
- ACSS2 contributes to transcriptional regulation in Cajal-Retzius cells in a mouse model of Alzheimer’s diseaseGabor Egervári, Desi C. Alexander, Greg Donahue, Hua Huang, Connor Hogan, Mariel R. Mendoza, Benjamin Aaron Garcia, Nancy M. Bonini, Shelley L. Berger · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Tau seeding in neurons enabled by transient endolysosomal perforations are confined within endolysosomesAnwesha Sanyal, Gustavo Scanavachi, Elliott Somerville, Beren Aylan, Jose Inacio Costa-Filho, Forest A Brooks, John R. Dickson, Bradley T. Hyman, Tomas L. Kirchhausen · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Neuronal APOE4 alone is sufficient to drive tau pathology, neurodegeneration, and neuroinflammation in an Alzheimer’s disease mouse modelJessica R. Blumenfeld, Yaqiao Li, Min Joo Kim, Oscar Yip, Leon Yao, Samuel De Leon, Rebecca Fulthorpe, David M. Shostak, Zoe Platow, Kaylie Suan et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Hebbian plasticity: The elusive missing link at the heart of Alzheimer’s disease pathogenesis?Jeans, AlexanderF · 2023 · Neural Regeneration Research
- A Characterization of Epileptiform Activity Associated with TAU Seeding and Amyloid Pathology in the APPKM670/671NL.PS1/L166P and APP-KI Animal Models2022 · Journal of Neurology and Experimental Neuroscience
- Lateral geniculate body is spared of tau pathology in Pick diseaseKoping Chang, Alexander Barrett, Khoa Pham, Juan Carlos Troncoso · 2024 · Journal of Neuropathology & Experimental Neurology
- Inducing aggresome and stable tau aggregation in Neuro2a cells with an optogenetic toolShigeo Sakuragi, Tomoya Uchida, Naoki Kato, Boxiao Zhao, Toshiki Takahashi, A Hattori, Yoshihiro Sakata, Yoshiyuki Soeda, Akihiko Takashima, Hideaki� Yoshimura et al. · 2024 · Biophysics and Physicobiology
- Peripheral administration of blood from tau transgenic animals exacerbates brain tau-associated pathologyLaura Vegas‐Gomez, Matías Pizarro, Jesus Garcia-Martin, Maria Angeles Arredondo-Alcala, Bianca Bustamante, Carolina Gonzalez‐Silva, Soledad Matus, Rodrigo Díaz‐Espinoza, Antonia Gutiérrez, Rodrigo Morales et al. · 2025 · PLoS ONE
- Novel in situ seeding immunodetection assay uncovers neuronal-driven alpha-synuclein seeding in Parkinson’s diseaseMaria Otero‐Jimenez, Marcelina J. Wojewska, Simona Jogaudaite, David E. Miller, Sandra Gray‐Rodriguez, Gráinne Geoghegan, Laura Esther Abelleira, Tim J. Viney, Barbara Sárkány, Djordje O. Gveric et al. · 2025 · npj Parkinson s Disease
- Stepwise connectivity of the entorhinal cortex along connectomic gradients in Alzheimer’s diseaseJazlynn Xiu Min Tan, Min Su Kang, Yi‐Hsuan Yeh, Gleb Bezgin, Firoza Zubeida Lussier, Seok‐Jun Hong, Jonah Isen, Nesrine Rahmouni, Paolo Vitali, Maxime Montembeault et al. · 2025 · Brain Communications
- Rigor & Reproducibility: pH Adjustments of Papain with L-Cysteine Dissociation Solutions and Cell Media Using Phenol Red SpectrophotometryJoshua M. Hilner, Allison Turner, Calissa Vollmar-Zygarlenski, Larry J. Millet · 2025 · Biosensors
- Alzheimer’s Tau seeds-induced pathology enhances hippocampal extracellular diffusionJuan Estaún‐Panzano, Anna Lovisotto, Claire Mazzocco, Carolina Piva, Morgane Darricau, Ivo Calaresu, Quentin Gresil, Vincent Planche, Benjamin Dehay, Laurent Groc et al. · 2025 · Communications Biology
- Conformation-specific monoclonal antibodies reveal early Tau structural intermediates in Alzheimer’s diseaseGrigoria Tsaka, Aida Montserrat Pagès, Cristiano Brás De Sousa, Jeroen Lammertyn, Grzegorz Walkiewicz, Luis Aragão Gomes, Maya Imbrechts, Sophie Tops, Kolla Rajasekhar, Kevin Muwonge et al. · 2026 · Journal of Biological Chemistry
- Gut-microbiota-mediated host immune modulation: mechanisms, pathological dysbiosis, and therapeutic frontiersPradeesh Babu, Vidhya Prakash, Suja Subhash, Muralidharan Vanuopadath, Jayalekshmi Haripriyan, Karthika Rajan, Avani G. Anu, Sandhya Padmakumar, Geetha B. Kumar, Bipin G Nair et al. · 2026 · Frontiers in Cellular and Infection Microbiology
- Transmission iatrogène des protéines β-amyloïde et tau : importance clinique et pour la recherche biomédicale sur la maladie d’AlzheimerMarc Dhénain · 2021 · Bulletin de l Académie Nationale de Médecine
- Development and Characterization of Mouse-Specific Anti-Tau Monoclonal Antibodies: Relevance for Analysis of Murine Tau in Cerebrospinal FluidDina Rodrigues Martins, Marc Vandermeeren, Kristof Van Kolen, Eddy Brepoels, Marianne Borgers, Cindy Wintmolders, Charlotte Delay, Astrid Bottelbergs, Marc H. Mercken, Clara Theunis · 2023 · Journal of Alzheimer s Disease
- Wherefore Art Tau? Functional importance of site-specific tau phosphorylation in diverse subcellular domainsAmanda K. Schneeweis, Daniel T.S. Pak · 2023 · The International Journal of Biochemistry & Cell Biology
- Experimental Models of Tau AggregationKerstin Buck, Thomas Robert Jahn, Laura Gasparini · 2018 · Elsevier eBooks
- Hsp70-Family Proteins and Neurodegenerative DiseasesZheying Sun, Roy J. Blackburn, Laura J. Blair, John Koren · 2018 · Heat shock proteins
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- Super-Resolution Imaging Uncovers Nanoscale Tau Aggregate Hyperphosphorylation Patterns in Human Alzheimer’s Disease Brain TissueAdriana Naomi Santiago-Ruiz, Siewert Hugelier, Charles R. Bond, Edward B. Lee, Melike Lakadamyali · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
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- Intrahippocampal delivery of hyperphosphorylated human tau oligomers induces neurodegeneration in non-transgenic wildtype miceHong‐Ru Chen, Hsiao‐Tien Chien Hagar, Kuan-Wei Wang, Stacy Hovde, Hsiao‐Yun Lin, Min-Hsuan Lin, Cheng-Chun Chang, Ching-Yung Wang, Chia-Yen Chen, Emily J. Bian et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Patient-derived tau-seeded human neuronal chimeras recapitulate mature Alzheimer’s tau pathology and uncover human-specific neuronal vulnerabilityYanru Ji, Purba Mandal, Jiahui Liu, Wen Hu, Bryce David Colon, Changlin Wan, Raymond W. Pan, Dongkai Guo, Lijia Zhang, Xingjian Gu et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Mechanistic Insight into Tau Fibril Cross-Seeding Barriers: Structural Order and DisorderHilary A. Weismiller · 2019 · Digital Commons - DU (University of Denver)
- Investigation of the intercellular transmission of α-synuclein, amyloid-β and TDP-43Christopher Sackmann · 2019 · Linköping University medical dissertations
- The Analysis of Exosomal Tau Release and its RegulationAaron Bradshaw · 2018 · UCL Discovery (University College London)
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- Host Tau Genotype Specifically Regulates and Designs Tau Seeding and Spreading Following Intracerebral Injection of Identical Tau ADInoculumPol Andrés‐Benito, Margarita Carmona, Mónica Jordán, José Antonio del Rı́o, Isidró Ferrer · 2021 · Research Square
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- Prion infections and tauopathy in animal models: disease progression and proteolysisGhazaleh Eskandari‐Sedighi · 2020 · ERA: Education and Research Archive (University of Alberta)
- 実験核物理領域,理論核物理領域「LHCとRHICの競演が拓く新世代のクォーク・グルーオン・プラズマ物性」(2012年秋季大会シンポジウムの報告,学会報告)進 佐藤 · 2013 · 日本物理學會誌
- Faculty Opinions recommendation of Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.Dongsheng Cai · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Systematic comparison of the molecular mechanisms underlying the spreading of pathology in different neurodegenerative diseasesInês Caldeira Brás · 2021 · eDiss (Georg-August-Universität Göttingen)
- Alzheimer’s Disease Drug Discovery in Academia: From High-Throughput Screening to In Vivo TestingKurt R. Brunden, Goodwell Nzou, Carlo Ballatore · 2022 · Cambridge University Press eBooks
- Faculty Opinions recommendation of LRP1 is a master regulator of tau uptake and spread.Giampietro Schiavo, Edoardo Moretto · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.Richard J Naftalin · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Host Tau Genotype Specifically Regulates and Designs Tau Seeding and Spreading Following Intracerebral Injection of Identical Tau AD InoculumPol Andrés‐Benito, Margarita Carmona, Mónica Jordán, José Antonio del Rı́o, Isidró Ferrer · 2021 · Research Square
- Faculty Opinions recommendation of Structures of filaments from Pick's disease reveal a novel tau protein fold.Berl R. Oakley · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- The Mechanistic Approach Involved in the Progression of Neurodegenerative DisordersMashoque Ahmad Rather, Andleeb Khan, Saeed Alsharani, Sadaf Jahan, Arif Jamal Siddiqui, Sidharth Mehan, Athanasios T. Alexiou · 2023 · Springer eBooks
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- Post-mortem AT-8 reactive tau species correlate with non-plaque Aβ levels in the frontal cortex of non-AD and AD brainsNauman Malik, Mohi-Uddin Miah, Alessandro Galgani, Kirsty E. McAleese, Lauren Walker, Fiona E. N. LeBeau, Johannes Attems, Tiago F. Outeiro, Alan J. Thomas, David J. Koss · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Involvement of the cellular prion protein in seeding and spreading of sarkosyl-derived fractions of Alzheimer’s disease in Prnp mutant mice and in the P301S transgenic tauopathy mice modelJulia Sala‐Jarque, Vanessa Gil, Pol Andrés‐Benito, Laia Lidón, Renato Eduardo Yanac-Huertas, Clara F. López-León, Félix Hernández, Jesús Ávila, José Luis Lanciego, Jordi Soriano et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
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- Generation of disease-specific amyloid structures and analysis of pathogenesisYasushi Yabuki · 2024 · Folia Pharmacologica Japonica
- The cellular prion protein does not affect tau seeding and spreading of sarkosyl-insoluble fractions from Alzheimer’s diseaseJulia Sala‐Jarque, Vanessa Gil, Pol Andrés‐Benito, Inés Martínez-Soria, Pol Picón-Pagès, Félix Hernández, Jesús Ávila, José Luis Lanciego, Mario Nuvolone, Adriano Aguzzi et al. · 2024 · Scientific Reports
- Structural polymorphism in amyloids—states within proteins’ solid-stateShailendra Dhakal, Vijayaraghavan Rangachari · 2024 · Elsevier eBooks
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- The Christchurch point mutation in mouse APOE reduces Aβ-induced tau and α-synuclein pathologiesCarlos M. Soto-Faguás, Abigail O’Niel, Paul A. Mueller, Paula Sanchez-Molina, Randy L Woltjer, Jacob Raber, Vivek K. Unni · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathyChristopher M. Brown, Jeanne Kaye Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Octavia Carare, Justin D. Boyd · 2025 · Brain Pathology
- Additional file 2 of Comparison of size distribution and (Pro249-Ser258) epitope exposure in in vitro and in vivo derived Tau fibrilsAndré Filipe Domingos Marreiro, Kristof Van Kolen, Sousa, Cristiano, Temmerman, Liesbet, Bruno Vasconcelos, Rosa Crespo Rodriguez, van Weering, Jan R. T., Debby Van Dam, De Deyn, Peter P., Adrian C. Apetri et al. · 2020 · Figshare