The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Organ-specific lymphatic vasculature: From development to pathophysiology
Open accessAbstract
Recent discoveries of novel functions and diverse origins of lymphatic vessels have drastically changed our view of lymphatic vasculature. Traditionally regarded as passive conduits for fluid and immune cells, lymphatic vessels now emerge as active, tissue-specific players in major physiological and pathophysiological processes. Lymphatic vessels show remarkable plasticity and heterogeneity, reflecting their functional specialization to control the tissue microenvironment. Moreover, alternative developmental origins of lymphatic endothelial cells in some organs may contribute to the diversity of their functions in adult tissues. This review aims to summarize the most recent findings of organotypic differentiation of lymphatic endothelial cells in terms of their distinct (patho)physiological functions in skin, lymph nodes, small intestine, brain, and eye. We discuss recent advances in our understanding of the heterogeneity of lymphatic vessels with respect to the organ-specific functional and molecular specialization of lymphatic endothelium, such as the hybrid blood-lymphatic identity of Schlemm’s canal, functions of intestinal lymphatics in dietary fat uptake, and discovery of meningeal lymphatic vasculature and perivascular brain lymphatic endothelial cells.
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A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
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Single-cell RNA sequencing to explore immune cell heterogeneity
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Angiocrine functions of organ-specific endothelial cells
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Cited by
Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid
Ahn, J. H., Cho, H., Kim, J.-H., Kim, S. H., Ham, J.-S., Park, I., Suh, S. H., Hong, S. P., Song, J.-H., Hong, Y.-K., et al. (2019) · Nature · doi:10.1038/s41586-019-1419-5 · Cited by 811
Self-citationLymphatic endothelial cells of the lymph node
Jalkanen, S., & Salmi, M. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0281-x · Cited by 226
Anatomy and function of the vertebral column lymphatic network in mice
Jacob, L., Boisserand, L. S. B., Geraldo, L. H. M., de Brito Neto, J., Mathivet, T., Antila, S., Barka, B., Xu, Y., Thomas, J.-M., Pestel, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12568-w · Cited by 144
Development and aging of the lymphatic vascular system
González-Loyola, A., & Petrova, T. V. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.005 · Cited by 89
Self-citationEndothelial sensing of AHR ligands regulates intestinal homeostasis
Wiggins, B. G., Wang, Y.-F., Burke, A., Grunberg, N., Vlachaki Walker, J. M., Dore, M., Chahrour, C., Pennycook, B. R., Sanchez-Garrido, J., Vernia, S., et al. (2023) · Nature · doi:10.1038/s41586-023-06508-4 · Cited by 89
Metadata
- Authors
- Petrova, T. V., & Koh, G. Y.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2017-12-14
- Volume
- 215
- Issue
- 1
- Pages
- 35-49
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2772071913
- Cited by
- 304
- References
- 118
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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