The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Inflammasome signaling and regulation of interleukin-1 family cytokines
Open accessAbstract
Specific IL-1 family cytokines are expressed by cells as cytosolic pro-forms that require cleavage for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and secretion is governed by inflammatory caspases within signaling platforms called inflammasomes. By inducing pyroptosis, inflammasomes can also drive the release of the alarmin IL-1α. Recent advances have transformed our mechanistic understanding of inflammasome signaling, cell death decisions, and cytokine activation and secretion. Here, we provide an updated view of inflammasome signaling; mechanisms underpinning IL-1α, IL-1β, IL-18, and IL-37 maturation and release; and the functions of these cytokines in protective and pathological inflammation.
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Cites
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Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice
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Metadata
- Authors
- Chan, A. H., & Schroder, K.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2019-10-14
- Volume
- 217
- Issue
- 1
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2980821196
- Cited by
- 373
- References
- 107
- FWCI
- 10.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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