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THE USE OF YELLOW FEVER VIRUS MODIFIED BY IN VITRO CULTIVATION FOR HUMAN IMMUNIZATION
Open accessAbstract
The response of rhesus monkeys to a subcutaneous inoculation with varying amounts of virus modified by prolonged cultivation in vitro has been studied. The tissue components of the medium consisted of chick embryo tissue containing minimal amounts of nervous tissue. The immunity produced in monkeys, as measured by the antibody titer developed, has no relation to the amount of virus inoculated. Monkeys inoculated subcutaneously with the tissue culture virus are rendered immune to a subsequent injection of a highly virulent yellow fever virus. This resistance is already present 7 days after vaccination. The subcutaneous inoculation of the culture virus into immune persons leads to a substantial increase of the serum antibody titer. The results of vaccinating eight normal persons with culture virus are presented. The reactions were minimal. The highest temperature recorded following vaccination was 37.4°C. The sera taken from the eight vaccinated persons 2 to 4 weeks after inoculation with the tissue culture virus showed the presence of yellow fever antibodies.
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Cited by
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Rey, F. A., Heinz, F. X., Mandl, C., Kunz, C., & Harrison, S. C. (1995) · Nature · doi:10.1038/375291a0 · Cited by 1,437
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
Querec, T. D., Akondy, R. S., Lee, E. K., Cao, W., Nakaya, H. I., Teuwen, D., Pirani, A., Gernert, K., Deng, J., Marzolf, B., et al. (2009) · Nature Immunology · doi:10.1038/ni.1688 · Cited by 1,121
Nucleotide Sequence of Yellow Fever Virus: Implications for Flavivirus Gene Expression and Evolution
Rice, C. M., Lenches, E. M., Eddy, S. R., Shin, S. J., Sheets, R. L., & Strauss, J. H. (1985) · Science · doi:10.1126/science.4023707 · Cited by 961
Vaccines: past, present and future
Plotkin, S. A. (2005) · Nature Medicine · doi:10.1038/nm1209 · Cited by 592
RNA Virus Populations as Quasispecies
Holland, J. J., De La Torre, J. C., & Steinhauer, D. A. (1992) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-77011-1_1 · Cited by 512
Metadata
- Authors
- Theiler, M., & Smith, H. H.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1937-06-01
- Volume
- 65
- Issue
- 6
- Pages
- 787-800
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1978711639
- Cited by
- 445
- References
- 0
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: THE USE OF YELLOW FEVER VIRUS MODIFIED BY IN VITRO CULTIVATION FOR HUMAN IMMUNIZATION. https://app.cochat.ai/papers/10.1084/jem.65.6.787
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- Theiler, M., & Smith, H. H. (1937). THE USE OF YELLOW FEVER VIRUS MODIFIED BY IN VITRO CULTIVATION FOR HUMAN IMMUNIZATION. Journal of Experimental Medicine. https://doi.org/10.1084/jem.65.6.787
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
