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THE DOMINANT ROLE OF THE LIVER IN PLASMA PROTEIN SYNTHESIS
Open accessAbstract
A direct study of the isolated rat liver perfused with oxygenated blood containing amino acids and lysine-ϵ-C14 has yielded facts indicating that the liver synthesizes practically all the plasma fibrinogen, the albumin fraction, and probably more than 80 per cent of the plasma globulin fraction. The response of the isolated perfused liver in protein synthesis is qualitatively and quantitatively analogous to that of the intact animal, notably in (a) the ability to discriminate between natural L-lysine and D-lysine, (b) the per cent of isotopic amino acid converted to CO2, (c) the per cent utilized in liver and plasma protein synthesis. The results obtained with the perfused liver are compared and contrasted with those reported for tissue homogenates, minces, and slices.
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Citations
Cited by
Interleukin-6 and the acute phase response
Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734
Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280
The role of albumin in critical illness
Nicholson, J. P., Wolmarans, M. R., & Park, G. R. (2000) · British Journal of Anaesthesia · doi:10.1093/bja/85.4.599 · Cited by 939
Gluconeogenesis in the perfused rat liver
Hems, R., Ross, B., Berry, M., & Krebs, H. (1966) · Biochemical Journal · doi:10.1042/bj1010284 · Cited by 719
Acute-Phase Reactants: Their Synthesis, Turnover and Biological Significance
Koj, A. (1974) · Structure and Function of Plasma Proteins · doi:10.1007/978-1-4684-2676-2_4 · Cited by 391
Metadata
- Authors
- Miller, L. L., Bly, C. G., Watson, M. L., & Bale, W. F.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1951-11-01
- Volume
- 94
- Issue
- 5
- Pages
- 431-453
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2069143100
- Cited by
- 808
- References
- 0
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Miller, L. L., Bly, C. G., Watson, M. L., & Bale, W. F. (1951). THE DOMINANT ROLE OF THE LIVER IN PLASMA PROTEIN SYNTHESIS. Journal of Experimental Medicine. https://doi.org/10.1084/jem.94.5.431
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
