The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Adrenaline Stimulates Glucagon Secretion in Pancreatic A-Cells by Increasing the Ca2+ Current and the Number of Granules Close to the L-Type Ca2+ Channels
Open accessAbstract
We have monitored electrical activity, voltage-gated Ca2+ currents, and exocytosis in single rat glucagon-secreting pancreatic A-cells. The A-cells were electrically excitable and generated spontaneous Na+- and Ca2+-dependent action potentials. Under basal conditions, exocytosis was tightly linked to Ca2+ influx through ω-conotoxin-GVIA–sensitive (N-type) Ca2+ channels. Stimulation of the A-cells with adrenaline (via β-adrenergic receptors) or forskolin produced a greater than fourfold PKA-dependent potentiation of depolarization-evoked exocytosis. This enhancement of exocytosis was due to a 50% enhancement of Ca2+ influx through L-type Ca2+ channels, an effect that accounted for <30% of the total stimulatory action. The remaining 70% of the stimulation was attributable to an acceleration of granule mobilization resulting in a fivefold increase in the number of readily releasable granules near the L-type Ca2+ channels.
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Cites
Multiple types of neuronal calcium channels and their selective modulation
Tsien, R. W., Lipscombe, D., Madison, D. V., Bley, K. R., & Fox, A. P. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90194-4 · Cited by 1,381
Glucagon physiology and pathophysiology in the light of new advances
Unger, R. H. (1985) · Diabetologia · doi:10.1007/bf00281991 · Cited by 361
Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM
Dinneen, S., Alzaid, A., Turk, D., & Rizza, R. (1995) · Diabetologia · doi:10.1007/bf00400639 · Cited by 190
Interplay of Nutrients and Hormones in the Regulation of Glucagon Release*
PIPELEERS, D. G., SCHUIT, F. C., SCHRAVENDIJK, C. F. H. V., & WINKEL, M. V. D. (1985) · Endocrinology · doi:10.1210/endo-117-3-817 · Cited by 169
Rorsman, P., & Hellman, B. (1988) · The Journal of general physiology · doi:10.1085/jgp.91.2.223 · Cited by 97
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Cited by
Mechanisms and Physiological Significance of the Cholinergic Control of Pancreatic β-Cell Function
Gilon, P., & Henquin, J.-C. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.5.0440 · Cited by 508
The metabolic actions of glucagon revisited
Habegger, K. M., Heppner, K. M., Geary, N., Bartness, T. J., DiMarchi, R., & Tschöp, M. H. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.187 · Cited by 406
The New Biology and Pharmacology of Glucagon
Müller, T. D., Finan, B., Clemmensen, C., DiMarchi, R. D., & Tschöp, M. H. (2017) · Physiological Reviews · doi:10.1152/physrev.00025.2016 · Cited by 419
Islet β-cell secretion determines glucagon release from neighbouring α-cells
Ishihara, H., Maechler, P., Gjinovci, A., Herrera, P.-L., & Wollheim, C. B. (2003) · Nature Cell Biology · doi:10.1038/ncb951 · Cited by 383
Franklin, I., Gromada, J., Gjinovci, A., Theander, S., & Wollheim, C. B. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1808 · Cited by 299
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Metadata
- Authors
- Gromada, J., Bokvist, K., Ding, W.-G., Barg, S., Buschard, K., Renström, E., & Rorsman, P.
- Venue
- The Journal of General Physiology
- Publisher
- Rockefeller University Press
- Published
- 1997-09-01
- Volume
- 110
- Issue
- 3
- Pages
- 217-228
- ISSN
- 0022-1295 (ISSN-L)
- 1540-7748
- OpenAlex
- W1988801692
- Cited by
- 187
- References
- 5
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Adrenaline Stimulates Glucagon Secretion in Pancreatic A-Cells by Increasing the Ca2+ Current and the Number of Granules Close to the L-Type Ca2+ Channels. https://app.cochat.ai/papers/10.1085/jgp.110.3.217
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- Gromada, J., Bokvist, K., Ding, W.-G., Barg, S., Buschard, K., Renström, E., & Rorsman, P. (1997). Adrenaline Stimulates Glucagon Secretion in Pancreatic A-Cells by Increasing the Ca2+ Current and the Number of Granules Close to the L-Type Ca2+ Channels. The Journal of General Physiology. https://doi.org/10.1085/jgp.110.3.217
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
