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Kcsa
Open accessAbstract
Ion conduction and selectivity properties of KcsA, a bacterial ion channel of known structure, were studied in a planar lipid bilayer system at the single-channel level. Selectivity sequences for permeant ions were determined by symmetrical solution conductance (K+ > Rb+, NH4+, Tl+ ≫ Cs+, Na+, Li+) and by reversal potentials under bi-ionic or mixed-ion conditions (Tl+ > K+ > Rb+ > NH4+ ≫ Na+, Li+). Determination of reversal potentials with submillivolt accuracy shows that K+ is over 150-fold more permeant than Na+. Variation of conductance with concentration under symmetrical salt conditions is complex, with at least two ion-binding processes revealing themselves: a high affinity process below 20 mM and a low affinity process over the range 100–1,000 mM. These properties are analogous to those seen in many eukaryotic K+ channels, and they establish KcsA as a faithful structural model for ion permeation in eukaryotic K+ channels.
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Citations
Cited by
Energetic optimization of ion conduction rate by the K+ selectivity filter
Morais-Cabral, J. H., Zhou, Y., & MacKinnon, R. (2001) · Nature · doi:10.1038/35102000 · Cited by 761
Piezo1 Channels Are Inherently Mechanosensitive
Syeda, R., Florendo, M. N., Cox, C. D., Kefauver, J. M., Santos, J. S., Martinac, B., & Patapoutian, A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.033 · Cited by 532
HKT transporter-mediated salinity resistance mechanisms in Arabidopsis and monocot crop plants
Horie, T., Hauser, F., & Schroeder, J. I. (2009) · Trends in Plant Science · doi:10.1016/j.tplants.2009.08.009 · Cited by 517
Functional Bionetworks from Nanoliter Water Droplets
Holden, M. A., Needham, D., & Bayley, H. (2007) · Journal of the American Chemical Society · doi:10.1021/ja072292a · Cited by 349
Principles of conduction and hydrophobic gating in K + channels
Jensen, M. Ø., Borhani, D. W., Lindorff-Larsen, K., Maragakis, P., Jogini, V., Eastwood, M. P., Dror, R. O., & Shaw, D. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911691107 · Cited by 311
Metadata
- Authors
- LeMasurier, M., Heginbotham, L., & Miller, C.
- Venue
- The Journal of General Physiology
- Publisher
- Rockefeller University Press
- Published
- 2001-08-27
- Volume
- 118
- Issue
- 3
- Pages
- 303-314
- ISSN
- 0022-1295 (ISSN-L)
- 1540-7748
- OpenAlex
- W2109258309
- Cited by
- 345
- References
- 0
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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