TUBULAR SECRETION OF CREATINE, TRIMETHYLAMINE OXIDE, AND OTHER ORGANIC BASES BY THE AGLOMERULAR KIDNEY OF LOPHIUS AMERICANUS
Open accessAbstract
Creatine and trimethylamine oxide (TMAO) are the chief nitrogenous constituents of normal Lophius urine, and both of these organic bases characteristically have high urine/plasma concentration ratios. Competition studies involving various organic bases indicate that creatine and TMAO are excreted independently by separate transport mechanisms. TMAO excretion is inhibited competitively by tetraethylammonium ion (TEA) and by cyanine dye No. 863—compounds previously shown to be transferred actively by an organic base-secreting mechanism of general occurrence among vertebrates. TEA does not inhibit competitively the active tubular reabsorption of TMAO in Squalus with doses which markedly depress its tubular excretion in Lophius. Glycine, which inhibits creatine reabsorption in the dog, does not interfere competitively with its secretion in Lophius.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a CD1 mouse model, high TMAO levels increased myocardial contractility and calcium flux in a dose-dependent manner.
“However, different findings were observed in a CD1 mouse model from Oakley et al. which showed that high levels TMAO has direct effects on increases in myocardial contractility and calcium flux in a dose-dependent manner187.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [187]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A MICROCOLORIMETRIC DETERMINATION OF CREATINE IN URINE BY THE JAFFE REACTION
Taussky, H. H., & Kurzmann, G. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65610-8 · Cited by 609 · see citing works
Determination of Inulin by Means of Resorcinol
SCHREINER, G. E. (1950) · Experimental Biology and Medicine · doi:10.3181/00379727-74-17827 · Cited by 389 · see citing works
‘Benemid,’ p-(di-n-Propylsulfamyl)-Benzoic Acid: Its Renal Affinity and Its Elimination
Beyer, K. H., Russo, H. F., Tillson, E. K., Miller, A. K., Verwey, W. F., & Gass, S. R. (1951) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1951.166.3.625 · Cited by 158 · see citing works
Active Cellular Transport of Urea by Frog Renal Tubules
Forster, R. P. (1954) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1954.179.2.372 · Cited by 70 · see citing works
Self-citationBerglund, F., & Forster, R. P. (1958) · The Journal of General Physiology · doi:10.1085/jgp.41.3.429 · Cited by 66 · see citing works
Self-citationForster, R. P., & Berglund, F. (1956) · The Journal of General Physiology · doi:10.1085/jgp.39.3.349 · Cited by 63 · see citing works
Self-citation'Benemid', p-(di-n-propylsulfamyl)-benzoic Acid: Inhibition of Glycine Conjugative Reactions
Beyer, K. H., Wiebelhaus, V. D., Tillson, E. K., Russo, H. F., & Wilhoyte, K. M. (1950) · Experimental Biology and Medicine · doi:10.3181/00379727-74-18043 · Cited by 44 · see citing works
RENAL TUBULAR ELIMINATION OF N1-METHYLNICOTINAMIDE
Beyer, K. H., Russo, H. F., Gass, S. R., et al. (1950) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1950.160.2.311 · Cited by 38 · see citing works
BRADY, T. G. (2008) · PubMed · Cited by 34 · see citing works
Rennick, B. R., Kandel, A., & Peters, L. (1956) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11728-x · Cited by 32 · see citing works
Self-citationEffect of Various Amino Acids on the Renal Tubular Reabsorption of Inorganic Sulfate in the Dog
Berglund, F., & Lotspeich, W. D. (1956) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1956.185.3.539 · Cited by 24 · see citing works
Self-citationRenal tubular secretion of tetraethylammonium in the dog and the chicken.
Rennick, B. R., Calhoon, D. M., Gandia, H., et al. (1954) · PubMed · Cited by 24 · see citing works
Self-citationInhibition of Uric Acid Exeretion in Rabbits given Probenecid or Salicylic Acid.
Poulsen, H. (1955) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1955.tb00227.x · Cited by 21 · see citing works
STUDIES ON THE RENAL TUBULAR TRANSPORT OF TETRAETHYLAMMONIUM ION IN THE DOG
Rennick, B. R., & FARAH, A. E. (1956) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11750-3 · Cited by 20 · see citing works
Self-citationForster, R. P., & Berglund, F. (1957) · Journal of Cellular and Comparative Physiology · doi:10.1002/jcp.1030490209 · Cited by 18 · see citing works
Self-citationRenal Secretion of Thiosulfate in the Dog
Foulks, J. G., Brazeau, P., Koelle, E. S., et al. (1951) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1951.168.1.77 · Cited by 16 · see citing works
Peters, L., FENTON, K. J., Wolf, M., et al. (1955) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11497-3 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dietary metabolism, the gut microbiome, and heart failure
Tang, W. H. W., Li, D. Y., & Hazen, S. L. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0108-7 · Cited by 789 · see citing works
- Authors
- Forster, R. P., Berglund, F., & Rennick, B. R.
- Affiliations
- Dartmouth College (US)
- ORCID
- Forster, Roy P.
- Venue
- The Journal of General Physiology
- Publisher
- Rockefeller University Press
- Published
- 1958-11-20
- Volume
- 42
- Issue
- 2
- Pages
- 319-327
- ISSN
- 0022-1295 (ISSN-L)
- 1540-7748
- PMC
- PMC2194903
- OpenAlex
- W2141077763
- Cited by
- 24
- References
- 17
- Citations by year
- 2023: 1 · 2018: 2 · 2016: 1 · 2015: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of General Physiology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Rockefeller Foundation
- John Simon Guggenheim Memorial Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- renal tubular secretion, creatine, trimethylamine N-oxide, organic bases, Lophius americanus, competitive inhibition, tetraethylammonium, glycine, nitrogen excretion
- MeSH terms
- Amines, Animals, Biological Transport, Creatine, Dogs, Fishes, Kidney, Methylamines, Tetraethylammonium
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
