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Na, Cl, and Water Transport by Rat Ileum in Vitro
Open accessAbstract
Interrelationships between metabolism, NaCl transport, and water transport have been studied in an in vitro preparation of rat ileum. When glucose is present in the mucosal solution, Na and Cl both appear to be actively transported from mucosa to serosa while water absorption is passive and dependent on net solute transport. Removal of glucose from the mucosal solution or treatment with dinitrophenol, monoiodoacetate, or anoxia inhibits active salt transport and as a result, water absorption is also inhibited. The dependence of water absorption on metabolism can be explained as a secondary effect due to its dependence on active salt transport. The relationship between salt and water transport has been discussed in terms of a model system.
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Citations
Cited by
Pappenheimer, J. R., & Reiss, K. Z. (1987) · The Journal of Membrane Biology · doi:10.1007/bf02209145 · Cited by 522
Ion Transport in Isolated Rabbit Ileum
Schultz, S. G., & Zalusky, R. (1964) · The Journal of General Physiology · doi:10.1085/jgp.47.6.1043 · Cited by 513
Hirschhorn, N., Kinzie, J. L., Sachar, D. B., Northrup, R. S., Taylor, J. O., Ahmad, S. Z., & Phillips, R. A. (1968) · New England Journal of Medicine · doi:10.1056/nejm196807252790402 · Cited by 320
Drozdowski, L. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i11.1657 · Cited by 275
H + ‐coupled nutrient, micronutrient and drug transporters in the mammalian small intestine
Thwaites, D. T., & Anderson, C. M. H. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2005.029959 · Cited by 188
Metadata
- Authors
- Curran, P. F.
- Venue
- The Journal of General Physiology
- Publisher
- Rockefeller University Press
- Published
- 1960-07-01
- Volume
- 43
- Issue
- 6
- Pages
- 1137-1148
- ISSN
- 0022-1295 (ISSN-L)
- 1540-7748
- OpenAlex
- W2114172732
- Cited by
- 335
- References
- 0
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Curran, P. F. (1960). Na, Cl, and Water Transport by Rat Ileum in Vitro. The Journal of General Physiology. https://doi.org/10.1085/jgp.43.6.1137
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.