The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Decrease in Net Stool Output in Cholera during Intestinal Perfusion with Glucose-Containing Solutions
Abstract
The rate of intestinal fluid loss was decreased significantly in eight patients with cholera when electrolyte solutions containing glucose were administered intragastrically or into the intestine for periods of 12 to 32 hours. During alternating periods of perfusion without glucose, or without any perfusion, the rate of fluid loss did not differ significantly from the natural course of diarrhea in 25 control patients. Thus, the normal mechanism of enhancement of intestinal sodium absorption by an actively transported sugar seems intact in cholera. Where intravenous fluids are scarce in cholera-affected areas, oral electrolyte solutions containing glucose can supplement parenteral fluids in the treatment of cholera.
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Citations
Cites
A PHOTOMETRIC ADAPTATION OF THE SOMOGYI METHOD FOR THE DETERMINATION OF GLUCOSE
Nelson, N. (1944) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71980-7 · Cited by 10,370
Van Slyke, D. D., & Neill, J. M. (1924) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)85145-6 · Cited by 2,018
Ion Transport in Isolated Rabbit Ileum
Schultz, S. G., & Zalusky, R. (1964) · The Journal of General Physiology · doi:10.1085/jgp.47.6.1043 · Cited by 513
Cotlove, E., Trantham, H. V., & Bowman, R. L. (1958) · PubMed · Cited by 427
The mechanisms of sodium absorption in the human small intestine
Fordtran, J. S., Rector, F. C., & Carter, N. W. (1968) · Journal of Clinical Investigation · doi:10.1172/jci105781 · Cited by 358
Na, Cl, and Water Transport by Rat Ileum in Vitro
Curran, P. F. (1960) · The Journal of General Physiology · doi:10.1085/jgp.43.6.1137 · Cited by 335
Solute and Water Absorption by the Human Small Intestine
Schedl, H. P., & Clifton, J. (1963) · Nature · doi:10.1038/1991264a0 · Cited by 107
Cited by
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
Biology of Human Sodium Glucose Transporters
Wright, E. M., Loo, D. D. F., & Hirayama, B. A. (2011) · Physiological Reviews · doi:10.1152/physrev.00055.2009 · Cited by 1,430
Physiology of Intestinal Absorption and Secretion
Kiela, P. R., & Ghishan, F. K. (2016) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2016.02.007 · Cited by 752
“This mechanism was calculated to account for 5 liters of water absorption per day in the human intestine and formed the molecular basis of oral rehydration therapy aimed to control mortality associated with cholera and diarrheal diseases [17].”
BackgroundESPEN guidelines on chronic intestinal failure in adults
Pironi, L., Arends, J., Bozzetti, F., Cuerda, C., Gillanders, L., Jeppesen, P. B., Joly, F., Kelly, D., Lal, S., Staun, M., et al. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.01.020 · Cited by 722
Glucose transporters in the small intestine in health and disease
Koepsell, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02439-5 · Cited by 290
Metadata
- Authors
- Hirschhorn, N., Kinzie, J. L., Sachar, D. B., Northrup, R. S., Taylor, J. O., Ahmad, S. Z., & Phillips, R. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1968-07-25
- Volume
- 279
- Issue
- 4
- Pages
- 176-181
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2058115726
- Cited by
- 320
- References
- 7
- FWCI
- 16.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Decrease in Net Stool Output in Cholera during Intestinal Perfusion with Glucose-Containing Solutions. https://app.cochat.ai/papers/10.1056/nejm196807252790402
- The paper
- Hirschhorn, N., Kinzie, J. L., Sachar, D. B., Northrup, R. S., Taylor, J. O., Ahmad, S. Z., & Phillips, R. A. (1968). Decrease in Net Stool Output in Cholera during Intestinal Perfusion with Glucose-Containing Solutions. New England Journal of Medicine. https://doi.org/10.1056/nejm196807252790402
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
