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Differences in Na and Ca Spikes As Examined by Application of Tetrodotoxin, Procaine, and Manganese Ions
Open accessAbstract
The effects of tetrodotoxin, procaine, and manganese ions were examined on the Ca spike of the barnacle muscle fiber injected with Ca-binding agent as well as on the action potential of the ventricular muscle fiber of the frog heart. Although tetrodotoxin and procaine very effectively suppress the "Na spike" of other tissues, no suppressing effects are found on "Ca spike" of the barnacle fiber, while the initiation of the Ca spike is competitively inhibited by manganese ions. The initial rate of rise of the ventricular action potential is suppressed by tetrodotoxin and procaine but the plateau phase of the action potential is little affected. In contrast the suppressing effect of manganese ions is mainly on the plateau phase. The results suggest that the plateau phase of the ventricular action potential is related to the conductance increase in the membrane to Ca ions even though Na conductance change may also contribute to the plateau.
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Citations
Cited by
Voltage oscillations in the barnacle giant muscle fiber
Morris, C., & Lecar, H. (1981) · Biophysical Journal · doi:10.1016/s0006-3495(81)84782-0 · Cited by 2,302
Calcium and muscle contraction
Ebashi, S., & Endo, M. (1968) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(68)90023-0 · Cited by 1,754
Manganese action in brain function
Takeda, A. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00234-5 · Cited by 538
Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers.
Kass, R. S., & Tsien, R. W. (1975) · The Journal of general physiology · doi:10.1085/jgp.66.2.169 · Cited by 313
Action potentials in the rat chromaffin cell and effects of acetylcholine.
Brandt, B. L., Hagiwara, S., Kidokoro, Y., & Miyazaki, S. (1976) · The Journal of Physiology · doi:10.1113/jphysiol.1976.sp011638 · Cited by 310
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Metadata
- Authors
- Hagiwara, S., & Nakajima, S.
- Venue
- The Journal of General Physiology
- Publisher
- Rockefeller University Press
- Published
- 1966-03-01
- Volume
- 49
- Issue
- 4
- Pages
- 793-806
- ISSN
- 0022-1295 (ISSN-L)
- 1540-7748
- OpenAlex
- W2049470042
- Cited by
- 423
- References
- 0
- FWCI
- 14.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Hagiwara, S., & Nakajima, S. (1966). Differences in Na and Ca Spikes As Examined by Application of Tetrodotoxin, Procaine, and Manganese Ions. The Journal of General Physiology. https://doi.org/10.1085/jgp.49.4.793
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