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Cited by 313

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers.

Open access
Kass, R S, Tsien, R W·1975·The Journal of general physiology
DOI 10.1085/jgp.66.2.169
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Abstract

We studied the influence of Mn, La, and D600 on action potentials and plateau currents in cardiac Purkinje fibers. The Ca antagonists each abolished the second inward current, but they failed to act selectively. Voltage clamp experiments revealed two additional effects: decrease of slow outward current (iotachi) activation, and increase of net outward time-independent plateau current. These effects occurred at inhibitor concentrations used in earlier studies, and were essential to the reconstruction of observed Ca antagonist effects on electrical activity. The inhibitory influence of Mn, La, and D600 on iotachi suggested that iotachi activation might depend upon prior Ca entry. This hypothesis was not supported, however, when [Ca]omicron was varied: elevating [Ca]omicron enhanced Ca entry, but iotachi was nevertheless depressed. Thus, the results suggested instead that Ca antagonists and Ca ions have rather similar effects on iotachi, possibly mediated by changes in membrane surface charge.

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Metadata

Authors
Kass, R. S., & Tsien, R. W.
Venue
The Journal of general physiology
Publisher
Rockefeller University Press
Published
1975-08-01
Volume
66
Issue
2
Pages
169-192
ISSN
  • 0022-1295 (ISSN-L)
  • 1540-7748
DOI
10.1085/jgp.66.2.169
OpenAlex
W2116544026
Cited by
313
References
24
FWCI
15.01
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers. https://app.cochat.ai/papers/10.1085/jgp.66.2.169
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Kass, R. S., & Tsien, R. W. (1975). Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers. The Journal of general physiology. https://doi.org/10.1085/jgp.66.2.169

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.