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The Effect of Variation of Fitness
Abstract
In a species in equilibrium variation is mainly due to two causes. Some deleterious genes are being weeded out by selection at the same rate as they are produced by mutation. Others are preserved because the heterozygous form is fitter than either homozygote. In the former case the loss of fitness in the species is roughly equal to the sum of all mutation rates and is probably of the order of 5 per cent. It is suggested that this loss of fitness is the price paid by a species for its capacity for further evolution.
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Citations
Cited by
Drake, J. W., Charlesworth, B., Charlesworth, D., & Crow, J. F. (1998) · Genetics · doi:10.1093/genetics/148.4.1667 · Cited by 1,932
THE EVOLUTION OF SELF‐FERTILIZATION AND INBREEDING DEPRESSION IN PLANTS. I. GENETIC MODELS
Lande, R., & Schemske, D. W. (1985) · Evolution · doi:10.1111/j.1558-5646.1985.tb04077.x · Cited by 1,648
Chromosome inversions, local adaptation and speciation
Kirkpatrick, M., & Barton, N. (2006) · Genetics · doi:10.1534/genetics.105.047985 · Cited by 1,178
Mutation Accumulation and the Extinction of Small Populations
Lynch, M., Conery, J., & Burger, R. (1995) · The American Naturalist · doi:10.1086/285812 · Cited by 1,049
The origins, patterns and implications of human spontaneous mutation
Crow, J. F. (2000) · Nature Reviews Genetics · doi:10.1038/35049558 · Cited by 928
Metadata
- Authors
- Haldane, J. B. S.
- Venue
- The American Naturalist
- Publisher
- University of Chicago Press
- Published
- 1937-07
- Volume
- 71
- Issue
- 735
- Pages
- 337-349
- ISSN
- 0003-0147 (ISSN-L)
- 1537-5323
- OpenAlex
- W2091860339
- Cited by
- 620
- References
- 0
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
