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Epidemiology of Ciprofloxacin Resistance and Its Relationship to Extended-Spectrum -Lactamase Production in Klebsiella pneumoniae Isolates Causing Bacteremia
Open accessAbstract
A prospective study of Klebsiella pneumoniae bacteremia was performed in 12 hospitals in 7 countries. Of 452 episodes of bacteremia, 25 (5.5%) were caused by K. pneumoniae that was resistant in vitro to ciprofloxacin. Extended-spectrum beta-lactamase (ESBL) production was detected in 15 (60%) of 25 ciprofloxacin-resistant isolates, compared with 68 (16%) of 427 ciprofloxacin-susceptible strains (P=.0001). Multivariate analysis revealed that risk factors for ciprofloxacin resistance in K. pneumoniae included prior receipt of a quinolone (P=.0065) and an ESBL-producing strain (P=.012). In all, 18% of ESBL-producing isolates were also ciprofloxacin-resistant. Pulsed-field gel electrophoresis showed that 11 of the 15 ciprofloxacin-resistant ESBL-producing strains belonged to just 4 genotypes, suggesting that patient-to-patient transmission of such strains occurred. The close relationship between ESBL production and ciprofloxacin resistance is particularly worrisome because the first reported instance of plasmid-mediated ciprofloxacin resistance has been in an isolate of K. pneumoniae also possessing an ESBL.
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Citations
Cited by
Resistance in Gram-Negative Bacteria: Enterobacteriaceae
Paterson, D. L. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.03.013 · Cited by 874
Self-citationNeuhauser, M. M., Weinstein, R. A., Rydman, R., Danziger, L. H., Karam, G., & Quinn, J. P. (2003) · JAMA · doi:10.1001/jama.289.7.885 · Cited by 678
Plasmid-mediated quinolone resistance: an update
Rodríguez-Martínez, J. M., Velasco, C., Pascual, Á., Cano, M. E., Martínez-Martínez, L., Martínez-Martínez, L., & Pascual, Á. (2011) · Journal of Infection and Chemotherapy · doi:10.1007/s10156-010-0120-2 · Cited by 306
Metadata
- Authors
- Paterson, D. L., Mulazimoglu, L., Casellas, J. M., Ko, W.-C., Goossens, H., Von Gottberg, A., Mohapatra, S., Trenholme, G. M., Klugman, K. P., McCormack, J. G., & Yu, V. L.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-03-01
- Volume
- 30
- Issue
- 3
- Pages
- 473-478
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2129824469
- Cited by
- 386
- References
- 0
- FWCI
- 10.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Epidemiology of Ciprofloxacin Resistance and Its Relationship to Extended-Spectrum -Lactamase Production in Klebsiella pneumoniae Isolates Causing Bacteremia. https://app.cochat.ai/papers/10.1086/313719
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- Paterson, D. L., Mulazimoglu, L., Casellas, J. M., Ko, W.-C., Goossens, H., Von Gottberg, A., Mohapatra, S., Trenholme, G. M., Klugman, K. P., McCormack, J. G., & Yu, V. L. (2000). Epidemiology of Ciprofloxacin Resistance and Its Relationship to Extended-Spectrum -Lactamase Production in Klebsiella pneumoniae Isolates Causing Bacteremia. Clinical Infectious Diseases. https://doi.org/10.1086/313719
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
