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Cited by 467

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Epidemiology and Host- and Variety-Dependent Characteristics of Infection Due to Cryptococcus neoformans in Australia and New Zealand

Chen, Sharon, Sorrell, Tania, Nimmo, Graeme, Speed, Bryan, Currie, Bart, Ellis, David, Marriott, Deborah, Pfeiffer, Tania, Parr, Dinah, Byth, Karen·2000·Clinical Infectious Diseases

Abstract

A prospective population-based study was conducted in Australia and New Zealand during 1994-1997 to elucidate the epidemiology of cryptococcosis due to Cryptococcus neoformans var. neoformans (CNVN) and C. neoformans var. gattii (CNVG) and to relate clinical manifestations to host immune status and cryptococcal variety. The mean annual incidence per 10(6) population was 6.6 in Australia and 2.2 in New Zealand. Of 312 episodes, CNVN caused 265 (85%; 98% of the episodes in immunocompromised hosts) and CNVG caused 47 (15%; 44% of the episodes in immunocompetent hosts). The incidence of AIDS-associated cases in Australia declined annually (P<.001). Aborigines in rural or semirural locations (P<.001) and immunocompetent males (P<.001) were at increased risk of CNVG infection. Cryptococcomas in lung or brain were more common in immunocompetent hosts (P< or =.03) in whom there was an association only between lung cryptococcomas and CNVG. An AIDS-associated genetic profile of CNVN serotype A was confirmed by random amplification of polymorphic DNA analysis. Resistance to antifungal drugs was uncommon. The epidemiology of CNVN infection has changed substantially. Clinical manifestations of disease are influenced more strongly by host immune status than by cryptococcal variety.

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Metadata

Authors
Chen, S., Sorrell, T., Nimmo, G., Speed, B., Currie, B., Ellis, D., Marriott, D., Pfeiffer, T., Parr, D., & Byth, K.
Venue
Clinical Infectious Diseases
Published
2000-08
Volume
31
Issue
2
Pages
499-508
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
OpenAlex
W2092024253
Cited by
467
References
1
FWCI
7.73
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Epidemiology and Host- and Variety-Dependent Characteristics of Infection Due to Cryptococcus neoformans in Australia and New Zealand. https://app.cochat.ai/papers/10.1086/313992
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Chen, S., Sorrell, T., Nimmo, G., Speed, B., Currie, B., Ellis, D., Marriott, D., Pfeiffer, T., Parr, D., & Byth, K. (2000). Epidemiology and Host- and Variety-Dependent Characteristics of Infection Due to Cryptococcus neoformans in Australia and New Zealand. Clinical Infectious Diseases. https://doi.org/10.1086/313992

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