The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Evidence for Zanamivir Resistance in an Immunocompromised Child Infected with Influenza B Virus
Abstract
Zanamivir, a neuraminidase inhibitor, has shown promise as a drug to control influenza. During prolonged treatment with zanamivir, a mutant virus was isolated from an immunocompromised child infected with influenza B virus. A hemagglutinin mutation (198 Thr-->Ile) reduced the virus affinity for receptors found on susceptible human cells. A mutation in the neuraminidase active site (152 Arg-->Lys) led to a 1000-fold reduction in the enzyme sensitivity to zanamivir. When tested in ferrets, the mutant virus had less virulence than the parent; however, it had a growth preference over the parent in zanamivir-treated animals. Despite these changes, the sensitivity of the mutant virus to zanamivir assessed by a standard test in MDCK cells was unaffected. These data indicate that the current methods for monitoring resistant mutants are potentially flawed because no tissue culture system adequately reflects the receptor specificity of human respiratory tract epithelium.
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Cites
Rational design of potent sialidase-based inhibitors of influenza virus replication
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Burmeister, W. P., Ruigrok, R. W., & Cusack, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05026.x · Cited by 314
Evidence for host-cell selection of influenza virus antigenic variants
Schild, G. C., Oxford, J. S., de Jong, J. C., & Webster, R. G. (1983) · Nature · doi:10.1038/303706a0 · Cited by 314
Self-citationSafety and Efficacy of the Neuraminidase Inhibitor GG167 in Experimental Human Influenza
Hayden, F. G. (1996) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1996.03530280047035 · Cited by 291
Plaque inhibition assay for drug susceptibility testing of influenza viruses
Hayden, F. G., Cote, K. M., & Douglas, R. G. (1980) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.17.5.865 · Cited by 278
Ito, T., Suzuki, Y., Mitnaul, L., Vines, A., Kida, H., & Kawaoka, Y. (1997) · Virology · doi:10.1006/viro.1996.8323 · Cited by 264
Gambaryan, A. S., Tuzikov, A. B., Piskarev, V. E., Yamnikova, S. S., Lvov, D. K., Robertson, J. S., Bovin, N. V., & Matrosovich, M. N. (1997) · Virology · doi:10.1006/viro.1997.8572 · Cited by 261
Self-citationColman, P. M., Hoyne, P. A., & Lawrence, M. C. (1993) · Journal of Virology · doi:10.1128/jvi.67.6.2972-2980.1993 · Cited by 255
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Cited by
Functional balance between haemagglutinin and neuraminidase in influenza virus infections
Wagner, R., Matrosovich, M., & Klenk, H. (2002) · Reviews in Medical Virology · doi:10.1002/rmv.352 · Cited by 608
Self-citationZanamivir in the Prevention of Influenza Among Healthy Adults: A Randomized Controlled Trial
Monto, A. S., Robinson, D. P., Herlocher, M. L., Hinson, Jr., Elliott, M. J., & Crisp, A. (1999) · JAMA · doi:10.1001/jama.282.1.31 · Cited by 321
Resistance of influenza viruses to neuraminidase inhibitors — a review
MCKIMMBRESCHKIN, J. (2000) · Antiviral Research · doi:10.1016/s0166-3542(00)00103-0 · Cited by 320
Metadata
- Authors
- Gubareva, L. V., Matrosovich, M. N., Brenner, M. K., Bethell, R. C., & Webster, R. G.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-11
- Volume
- 178
- Issue
- 5
- Pages
- 1257-1262
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2164343098
- Cited by
- 432
- References
- 20
- FWCI
- 23.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Evidence for Zanamivir Resistance in an Immunocompromised Child Infected with Influenza B Virus. https://app.cochat.ai/papers/10.1086/314440
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- Gubareva, L. V., Matrosovich, M. N., Brenner, M. K., Bethell, R. C., & Webster, R. G. (1998). Evidence for Zanamivir Resistance in an Immunocompromised Child Infected with Influenza B Virus. The Journal of Infectious Diseases. https://doi.org/10.1086/314440
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
