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The Diverse Patterns of Hepatitis A Epidemiology in the United States—Implications for Vaccination Strategies
Abstract
Hepatitis A is the most frequently reported vaccine-preventable disease in the United States. Hepatitis A incidence and risk factors during 1983-1995 were examined among cases reported to the study's Sentinel Counties: Denver County, Colorado; Pierce County, Washington; Jefferson County, Alabama; and Pinellas County, Florida. Of 4897 serologically confirmed cases, 611 patients (13%) were hospitalized and 9 (0.2%) died. The average incidence was 14.7/100, 000 (range, 0.6-100.7/100,000, depending on county and year). The frequency of reported sources of infection varied by county, but the largest single group overall (52%) did not report a source. During 3-year communitywide outbreaks in Denver (1991-1993) and Pierce (1987-1989) Counties, rates increased 4- and 13-fold, respectively, and increased in all age, racial/ethnic, and risk groups. During communitywide outbreaks, hepatitis A is not limited to specific risk groups; sustained nationwide reductions in incidence are more likely to result from routine childhood vaccination than from targeted vaccination of high-risk groups.
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Cited by
Nelson, N. P., Weng, M. K., Hofmeister, M. G., Moore, K. L., Doshani, M., Kamili, S., Koneru, A., Haber, P., Hagan, L., Romero, J. R., et al. (2020) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr6905a1 · Cited by 264
Evolving public health approaches to the global challenge of foodborne infections
Tauxe, R. V., Doyle, M. P., Kuchenmüller, T., Schlundt, J., & Stein, C. E. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2009.10.014 · Cited by 201
Metadata
- Authors
- Bell, B. P., Shapiro, C. N., Alter, M. J., Moyer, L. A., Judson, F. N., Mottram, K., Fleenor, M., Ryder, P. L., & Margolis, H. S.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-12
- Volume
- 178
- Issue
- 6
- Pages
- 1579-1584
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2144560792
- Cited by
- 225
- References
- 0
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Diverse Patterns of Hepatitis A Epidemiology in the United States—Implications for Vaccination Strategies. https://app.cochat.ai/papers/10.1086/314518
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- Bell, B. P., Shapiro, C. N., Alter, M. J., Moyer, L. A., Judson, F. N., Mottram, K., Fleenor, M., Ryder, P. L., & Margolis, H. S. (1998). The Diverse Patterns of Hepatitis A Epidemiology in the United States—Implications for Vaccination Strategies. The Journal of Infectious Diseases. https://doi.org/10.1086/314518
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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