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Tuberculosis and Chronic Hepatitis B Virus Infection in Africans and Variation in the Vitamin D Receptor Gene
Abstract
The active metabolite of vitamin D, 1,25 dihydroxyvitamin D3, is an important immunoregulatory hormone [1]. Its effects are exerted by interaction with the vitamin D receptor, which is present on human monocytes and activated T and B lymphocytes. Variation in the vitamin D receptor gene was typed in 2015 subjects from large case-control studies of three major infectious diseases: tuberculosis, malaria, and hepatitis B virus. Homozygotes for a polymorphism at codon 352 (genotype tt) were significantly underrepresented among those with tuberculosis (chi2=6.22, 1 df, P=. 01) and persistent hepatitis B infection (chi2=6.25, 1 df, P=.01) but not in subjects with clinical malaria compared with the other genotypes. Therefore, this genetic variant, which predisposes to low bone mineral density in many populations, may confer resistance to certain infectious diseases.
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Citations
Cited by
Mendelian randomization: prospects, potentials, and limitations
Smith, G. D. (2004) · International Journal of Epidemiology · doi:10.1093/ije/dyh132 · Cited by 1,222
Genetic Dissection of Immunity to Mycobacteria: The Human Model
Casanova, J.-L., & Abel, L. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.081501.125851 · Cited by 991
Frieden, T. R., Sterling, T. R., Munsiff, S. S., Watt, C. J., & Dye, C. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14333-4 · Cited by 689
Genetics of susceptibitlity to human infectious disease
Cooke, G. S., & Hill, A. V. S. (2001) · Nature Reviews Genetics · doi:10.1038/35103577 · Cited by 444
Self-citationMartineau, A. R., Wilkinson, K. A., Newton, S. M., Floto, R. A., Norman, A. W., Skolimowska, K., Davidson, R. N., Sørensen, O. E., Kampmann, B., Griffiths, C. J., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.7190 · Cited by 410
Metadata
- Authors
- Bellamy, R., Ruwende, C., Corrah, T., McAdam, K. P. W. J., Thursz, M., Whittle, H. C., & Hill, A. V. S.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03
- Volume
- 179
- Issue
- 3
- Pages
- 721-724
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2034457488
- Cited by
- 436
- References
- 0
- FWCI
- 14.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bellamy, R., Ruwende, C., Corrah, T., McAdam, K. P. W. J., Thursz, M., Whittle, H. C., & Hill, A. V. S. (1999). Tuberculosis and Chronic Hepatitis B Virus Infection in Africans and Variation in the Vitamin D Receptor Gene. The Journal of Infectious Diseases. https://doi.org/10.1086/314614
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