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Meningococcal Serogroup C Conjugate Vaccine Is Immunogenic in Infancy and Primes for Memory
Abstract
The safety, immunogenicity, and immunologic priming of 2 dosages (2 microgram or 10 microgram) of a meningococcal C oligosaccharide-CRM197 conjugate vaccine was evaluated in 114 infants vaccinated at ages 2, 3, and 4 months. Antibody persistence and response to boosting with 10 microgram of meningococcal C polysaccharide were assessed. The meningococcal conjugate vaccine produced fewer local reactions than concurrent routine immunizations. Total serogroup C-specific immunoglobulin geometric mean concentration (GMC) increased from 0.3 microgram/mL before vaccination to 13.1 microgram/mL at age 5 months. Serum bactericidal antibody (SBA) geometric mean titers (GMTs) rose from <1:4 to 1:1057 at 5 months and fell by 14 months to 1:19. Following boosting, anti-C-specific immunoglobulin GMC rose to 15.9 microgram/mL and SBA GMT to 1:495. Antibody responses in the 10-microgram dose cohort were significantly higher at 5 months (P<.01) than in the 2-microgram dose cohort but were lower after polysaccharide boosting (P=.02). This meningococcal conjugate vaccine was well tolerated and immunogenic and induced immunologic memory in infants.
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Cited by
Borrow, R., Andrews, N., Goldblatt, D., & Miller, E. (2001) · Infection and Immunity · doi:10.1128/iai.69.3.1568-1573.2001 · Cited by 316
Self-citationMeningococcal C conjugate vaccine: the experience in England and Wales
Campbell, H., Borrow, R., Salisbury, D., & Miller, E. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.04.067 · Cited by 168
Self-citationPobre, K., Tashani, M., Ridda, I., Rashid, H., Wong, M., & Booy, R. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.01.047 · Cited by 76
Pace, D., Khatami, A., McKenna, J., Campbell, D., Attard-Montalto, S., Birks, J., Voysey, M., White, C., Finn, A., Macloed, E., et al. (2015) · BMJ · doi:10.1136/bmj.h1554 · Cited by 28
Self-citationZeng, W., Horrocks, K. J., Tan, A. C. L., Wong, C. Y., Chua, B. Y., & Jackson, D. C. (2020) · Vaccine · doi:10.1016/j.vaccine.2019.10.055 · Cited by 4
Metadata
- Authors
- Richmond, P., Borrow, R., Miller, E., Clark, S., Sadler, F., Fox, A., Begg, N., Morris, R., & Cartwright, K.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-06
- Volume
- 179
- Issue
- 6
- Pages
- 1569-1572
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2002678874
- Cited by
- 240
- References
- 0
- FWCI
- 15.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Richmond, P., Borrow, R., Miller, E., Clark, S., Sadler, F., Fox, A., Begg, N., Morris, R., & Cartwright, K. (1999). Meningococcal Serogroup C Conjugate Vaccine Is Immunogenic in Infancy and Primes for Memory. The Journal of Infectious Diseases. https://doi.org/10.1086/314753
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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