The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Chlamydia pneumoniae Infection Accelerates the Progression of Atherosclerosis in Apolipoprotein E–Deficient Mice
Abstract
Accumulating evidence supports an association between Chlamydia pneumoniae infection and atherosclerosis. To determine whether there is a causal relationship, the effects of chronic infection with C. pneumoniae on the development of atherosclerosis in apolipoprotein E (apoE)-deficient mice were evaluated. Eight-week-old male apoE-deficient mice were inoculated intranasally with C. pneumoniae three times, at 8, 9, and 10 weeks of age. The combined area of atherosclerotic lesions in the lesser curvature of the aortic arch was measured en face by computer-assisted morphometry. The lesion area was 2.4-fold greater (P=.05) at 16 weeks of age and 1.6-fold greater (P=.05) at 20 weeks of age in infected mice than in control mice. There were no differences in total plasma cholesterol levels between groups. This study demonstrates that C. pneumoniae infection accelerates the progression of atherosclerosis in the aortic arch of apoE-deficient mice.
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Citations
Cites
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693 · cited 1×
“pneumoniae in atherosclerosis, we evaluated the apoE-deficient mouse, a hyperlipidemic animal model that spontaneously develops atherosclerotic lesions that are morphologically similar to those in humans [6, 7].”
BackgroundPiedrahita, J. A., Zhang, S. H., Hagaman, J. R., Oliver, P. M., & Maeda, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4471 · Cited by 944
Cited by
Xu, X. H., Shah, P. K., Faure, E., Equils, O., Thomas, L., Fishbein, M. C., Luthringer, D., Xu, X.-P., Rajavashisth, T. B., Yano, J., et al. (2001) · Circulation · doi:10.1161/hc5001.100631 · Cited by 666
Castrillo, A., Joseph, S. B., Vaidya, S. A., Haberland, M., Fogelman, A. M., Cheng, G., & Tontonoz, P. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00384-8 · Cited by 488
Bulut, Y., Faure, E., Thomas, L., Karahashi, H., Michelsen, K. S., Equils, O., Morrison, S. G., Morrison, R. P., & Arditi, M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1435 · Cited by 405
Ann Campbell, L., & Rosenfeld, M. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-06-0392 · Cited by 363
Self-citationGibson, F. C., Hong, C., Chou, H.-H., Yumoto, H., Chen, J., Lien, E., Wong, J., & Attardo Genco, C. (2004) · Circulation · doi:10.1161/01.cir.0000129769.17895.f0 · Cited by 329
Metadata
- Authors
- Moazed, T. C., Campbell, L. A., Rosenfeld, M. E., Grayston, J. T., & Kuo, C.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-07
- Volume
- 180
- Issue
- 1
- Pages
- 238-241
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2114113492
- Cited by
- 248
- References
- 2
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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