The DOI matches its Crossref record.
Molecular Epidemiology of Tuberculosis in the Netherlands: A Nationwide Study from 1993 through 1997
Open accessAbstract
To disclose risk factors for active tuberculosis transmission in the Netherlands, restriction fragment length polymorphism (RFLP) patterns of 78% of the Mycobacterium tuberculosis isolates, from the period 1993-1997, were analyzed. Of the respective 4266 cases, 46% were found in clusters of isolates with identical RFLPs, and 35% were attributed to active transmission. The clustering percentage increased strongly with the number of isolates; taking this into account, fewer cases were clustered than has been reported in other studies. Contact investigations in the five largest clusters of 23-47 patients suggested epidemiological linkage between cases. Of patients identified through contact tracing, 91% were clustered. Demographic risk factors for active transmission of tuberculosis included male sex, urban residence, Dutch and Surinamese nationality, and long-term residence in the Netherlands. Human immunodeficiency virus infection was not an independent risk factor for active transmission. Isoniazid-resistant strains were relatively less frequently clustered, suggesting that these generated fewer secondary cases.
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Cited by
Antimicrobial resistance in developing countries. Part I: recent trends and current status
Okeke, I. N., Laxminarayan, R., Bhutta, Z. A., Duse, A. G., Jenkins, P., O'Brien, T. F., Pablos-Mendez, A., & Klugman, K. P. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70189-4 · Cited by 851
Controlling multidrug-resistant tuberculosis and access to expensive drugs: a rational framework.
(2002) · Europe PMC (PubMed Central) · Cited by 95
OLOYA, J., OPUDA-ASIBO, J., KAZWALA, R., DEMELASH, A. B., SKJERVE, E., LUND, A., JOHANSEN, T. B., & DJONNE, B. (2008) · Epidemiology and Infection · doi:10.1017/s0950268807009004 · Cited by 76
Metadata
- Authors
- van Soolingen, D., Borgdorff, M. W., de Haas, P. E. W., Sebek, M. M. G. G., Veen, J., Dessens, M., Kremer, K., & van Embden, J. D. A.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-09
- Volume
- 180
- Issue
- 3
- Pages
- 726-736
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2101580769
- Cited by
- 285
- References
- 0
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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