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Vaccination with FimH Adhesin Protects Cynomolgus Monkeys from Colonization and Infection by Uropathogenic Escherichia coli
Abstract
Escherichia coli FimH adhesin mediates binding to the bladder mucosa. In mice, a FimH vaccine protects against bacterial challenge. In this study, 4 monkeys were inoculated with 100 microgram of FimCH adhesin-chaperone complex mixed with MF59 adjuvant, and 4 monkeys were given adjuvant only intramuscularly. After 2 doses (day 0 and week 4), a booster at 48 weeks elicited a strong IgG antibody response to FimH in the vaccinated monkeys. All 8 monkeys were challenged with 1 mL of 108 E. coli cystitis isolate NU14. Three of the 4 vaccinated monkeys were protected from bacteruria and pyuria; all control monkeys were infected. These findings suggest that a vaccine based on the FimH adhesin of E. coli type 1 pili may have utility in preventing cystitis in humans.
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Cited by
Mulvey, M. A., Schilling, J. D., & Hultgren, S. J. (2001) · Infection and Immunity · doi:10.1128/iai.69.7.4572-4579.2001 · Cited by 849
Self-citationBacterial Adhesins in Host-Microbe Interactions
Kline, K. A., Fälker, S., Dahlberg, S., Normark, S., & Henriques-Normark, B. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.011 · Cited by 630
Self-citationMolecular mimicry in pauci-immune focal necrotizing glomerulonephritis
Kain, R., Exner, M., Brandes, R., Ziebermayr, R., Cunningham, D., Alderson, C. A., Davidovits, A., Raab, I., Jahn, R., Ashour, O., et al. (2008) · Nature Medicine · doi:10.1038/nm.1874 · Cited by 455
Anti-adhesion therapy of bacterial diseases: prospects and problems
Ofek, I., Hasty, D. L., & Sharon, N. (2003) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(03)00228-1 · Cited by 444
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Metadata
- Authors
- Langermann, S., Möllby, R., Burlein, J. E., Palaszynski, S. R., Auguste, C. G., DeFusco, A., Strouse, R., Schenerman, M. A., Hultgren, S. J., Pinkner, J. S., Winberg, J., Guldevall, L., Söderhäll, M., Ishikawa, K., Normark, S., & Koenig, S.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-02
- Volume
- 181
- Issue
- 2
- Pages
- 774-778
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2169478013
- Cited by
- 336
- References
- 0
- FWCI
- 9.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Langermann, S., Möllby, R., Burlein, J. E., Palaszynski, S. R., Auguste, C. G., DeFusco, A., Strouse, R., Schenerman, M. A., Hultgren, S. J., Pinkner, J. S., Winberg, J., Guldevall, L., Söderhäll, M., Ishikawa, K., Normark, S., & Koenig, S. (2000). Vaccination with FimH Adhesin Protects Cynomolgus Monkeys from Colonization and Infection by Uropathogenic Escherichia coli. The Journal of Infectious Diseases. https://doi.org/10.1086/315258
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