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Frequencies of Memory T Cells Specific for Varicella‐Zoster Virus, Herpes Simplex Virus, and Cytomegalovirus by Intracellular Detection of Cytokine Expression
Abstract
Memory T cells specific for varicella-zoster virus (VZV), herpes simplex virus (HSV), and human cytomegalovirus (HCMV) were compared in immune adults by intracellular cytokine (ICC) detection. The mean percentages of CD4+ T cells were 0.11% for VZV and 0.22% for HSV by interferon (IFN)-gamma production; the frequency for HCMV was significantly higher at 1.21%. Percentages of VZV-, HSV-, and HCMV-specific CD4+ T cells were similar by use of tumor necrosis factor (TNF)-alpha. HCMV-stimulated CD8+ T cells produced IFN-gamma (1.11%) and TNF-alpha (1.71%); VZV- and HSV-specific CD8+ T cells were not detectable. VZV CD4+ T cell numbers were similar in young adults with natural or vaccine-induced immunity. VZV CD4+ T cells were significantly less frequent in older adults. Secondary varicella immunization did not increase VZV-specific CD4+ T cell frequencies by ICC assay. Numbers of memory T cells specific for herpesviruses may vary with sites of viral latency and with host age.
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Cited by
Sylwester, A. W., Mitchell, B. L., Edgar, J. B., Taormina, C., Pelte, C., Ruchti, F., Sleath, P. R., Grabstein, K. H., Hosken, N. A., Kern, F., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050882 · Cited by 1,339
Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J. A., Sinclair, A. J., Nayak, L., & Moss, P. A. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1984 · Cited by 754
Mechanisms underlying T cell ageing
Goronzy, J. J., & Weyand, C. M. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0180-1 · Cited by 506
Levin, M. J., Smith, J. G., Kaufhold, R. M., Barber, D., Hayward, A. R., Chan, C. Y., Chan, I. S. F., Li, D. J. J., Wang, W., Keller, P. M., et al. (2003) · The Journal of Infectious Diseases · doi:10.1086/379048 · Cited by 314
Use of an Inactivated Varicella Vaccine in Recipients of Hematopoietic-Cell Transplants
Hata, A., Asanuma, H., Rinki, M., Sharp, M., Wong, R. M., Blume, K., & Arvin, A. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013441 · Cited by 300
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Metadata
- Authors
- Asanuma, H., Sharp, M., Maecker, H. T., Maino, V. C., & Arvin, A. M.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-03
- Volume
- 181
- Issue
- 3
- Pages
- 859-866
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2153293687
- Cited by
- 199
- References
- 0
- FWCI
- 13.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Asanuma, H., Sharp, M., Maecker, H. T., Maino, V. C., & Arvin, A. M. (2000). Frequencies of Memory T Cells Specific for Varicella‐Zoster Virus, Herpes Simplex Virus, and Cytomegalovirus by Intracellular Detection of Cytokine Expression. The Journal of Infectious Diseases. https://doi.org/10.1086/315347
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