The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Plasmodium falciparum–Infected Erythrocytes: Agglutination by Diverse Kenyan Plasma Is Associated with Severe Disease and Young Host Age
Abstract
The variant surface antigens (VSAs) of Plasmodium falciparum-infected red blood cells are potentially important targets of naturally acquired immunity to malaria. Natural infections induce agglutinating antibodies specific to the VSA variants expressed by the infecting parasites. Previously, when different parasite isolates were tested against a panel of heterologous plasma from Kenyan children, the proportion of plasma that agglutinated the parasites (the agglutination frequency [AF]) was highly variable among isolates, suggesting the existence of rare and prevalent variants. Here, the AF of 115 isolates from Kenyan children were compared. The results show that the AF of isolates causing severe malaria were significantly higher than those of isolates causing mild malaria; and AF decreased significantly with the increasing age of the infected child. We propose that parasites causing severe disease tend to express a subset of VSA variants that are preferentially associated with infections of children with low immunity.
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Self-citationRapid switching to multiple antigenic and adhesive phenotypes in malaria
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Self-citationNewbold, C. I., Pinches, R., Roberts, D. J., & Marsh, K. (1992) · Experimental Parasitology · doi:10.1016/0014-4894(92)90213-t · Cited by 144
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Cited by
Malaria in pregnancy: pathogenesis and immunity
Rogerson, S. J., Hviid, L., Duffy, P. E., Leke, R. F., & Taylor, D. W. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70022-1 · Cited by 628
Nielsen, M. A., Staalsoe, T., Kurtzhals, J. A. L., Goka, B. Q., Dodoo, D., Alifrangis, M., Theander, T. G., Akanmori, B. D., & Hviid, L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3444 · Cited by 207
Population Genomics of the Immune Evasion (var) Genes of Plasmodium falciparum
Barry, A. E., Leliwa-Sytek, A., Tavul, L., Imrie, H., Migot-Nabias, F., Brown, S. M., McVean, G. A. V., & Day, K. P. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030034 · Cited by 199
(2015) · Advances in Parasitology · doi:10.1016/bs.apar.2015.02.004 · Cited by 162
Trimnell, A. R., Kraemer, S. M., Mukherjee, S., Phippard, D. J., Janes, J. H., Flamoe, E., Su, X.-Z., Awadalla, P., & Smith, J. D. (2006) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2006.03.012 · Cited by 165
Metadata
- Authors
- Bull, P. C., Kortok, M., Kai, O., Ndungu, F., Ross, A., Lowe, B. S., Newbold, C. I., & Marsh, K.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-07
- Volume
- 182
- Issue
- 1
- Pages
- 252-259
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2114224389
- Cited by
- 173
- References
- 6
- FWCI
- 10.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bull, P. C., Kortok, M., Kai, O., Ndungu, F., Ross, A., Lowe, B. S., Newbold, C. I., & Marsh, K. (2000). Plasmodium falciparum–Infected Erythrocytes: Agglutination by Diverse Kenyan Plasma Is Associated with Severe Disease and Young Host Age. The Journal of Infectious Diseases. https://doi.org/10.1086/315652
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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