The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Human Infection with Ascaris lumbricoides Is Associated with a Polarized Cytokine Response
Abstract
To define the cytokine response to Ascaris lumbricoides infection, the cellular immune response to adult and larval-stage Ascaris antigens in young adults with moderate infection intensities (n=73) was compared with that of a group of uninfected control subjects (n=40). A. lumbricoides-infected subjects had significantly greater lymphoproliferative responses to adult and larval-stage antigens, compared with uninfected control subjects (P<.01). The frequencies of parasite antigen-stimulated peripheral blood mononuclear cell (PBMC)-expressing interleukin (IL)-4 and IL-5 were significantly greater in the infected group (P<.001), whereas the frequencies of IL-10- and interferon-gamma-expressing PBMC were similar in the 2 groups studied. The ratios of Th2 to Th1 cytokine frequencies were significantly elevated in the infected group, compared with those in uninfected subjects, as was IL-5 protein production by PBMC stimulated with adult (P<.05) and L3/L4 stage (P<.001) antigens. Analysis of these data indicates that A. lumbricoides infections in endemic regions are associated with a highly polarized type 2 cytokine response.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Finkelman, F. D., Shea-Donohue, T., Goldhill, J., Sullivan, C. A., Morris, S. C., Madden, K. B., Gause, W. C., & Urban, J. F. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.505 · Cited by 643
Self-citationThe global burden of intestinal nematode infections — Fifty years on
Chan, M.-S. (1997) · Parasitology Today · doi:10.1016/s0169-4758(97)01144-7 · Cited by 468
Actor, J. K., Shirai, M., Kullberg, M. C., Buller, R. M., Sher, A., & Berzofsky, J. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.948 · Cited by 353
Sabin, E. A., Araujo, M. I., Carvalho, E. M., & Pearce, E. J. (1996) · The Journal of Infectious Diseases · doi:10.1093/infdis/173.1.269 · Cited by 264
Production and Activities of IgE in Helminth Infection
Jarrett, E. E. E., & Miller, H. R. P. (2015) · Chemical Immunology and Allergy · doi:10.1159/000406534 · Cited by 263
Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen
Kullberg, M. C., Pearce, E. J., Hieny, S. E., Sher, A., & Berzofsky, J. A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.10.3264 · Cited by 251
Cooper, P. J., Espinel, I., Paredes, W., Guderian, R. H., & Nutman, T. B. (1998) · The Journal of Infectious Diseases · doi:10.1086/515661 · Cited by 175
Self-citationClinical Improvement of Asthma after Anthelminthic Treatment in a Tropical Situation
Lynch, N. R., Palenque, M., Hagel, I., & DiPRISCO, M. C. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.1.9606081 · Cited by 152
McSharry, C. P., Xia, Y., Holland, C. V., & Kennedy, M. W. (1999) · Infection and Immunity · doi:10.1128/iai.67.2.484-489.1999 · Cited by 152
Self-citation1. The global burden of intestinal nematode disease
Bundy, D. A. P. (1994) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(94)90069-8 · Cited by 151
Cited by
Cooper, P. J., Chico, M. E., Rodrigues, L. C., Ordonez, M., Strachan, D., Griffin, G. E., & Nutman, T. B. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1348 · Cited by 310
Self-citationWhipworm and roundworm infections
Else, K. J., Keiser, J., Holland, C. V., Grencis, R. K., Sattelle, D. B., Fujiwara, R. T., Bueno, L. L., Asaolu, S. O., Sowemimo, O. A., & Cooper, P. J. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0171-3 · Cited by 308
Interactions between helminth parasites and allergy
Cooper, P. J. (2009) · Current Opinion in Allergy & Clinical Immunology · doi:10.1097/aci.0b013e32831f44a6 · Cited by 202
Self-citationDo helminth parasites protect against atopy and allergic disease?
Flohr, C., Quinnell, R. J., & Britton, J. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.03134.x · Cited by 159
IgE responses to Ascaris and mite tropomyosins are risk factors for asthma
Ahumada, V., García, E., Dennis, R., Rojas, M. X., Rondón, M. A., Pérez, A., Peñaranda, A., Barragán, A. M., Jimenez, S., Kennedy, M. W., et al. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12513 · Cited by 69
Self-citation
Metadata
- Authors
- Cooper, P. J., Chico, M. E., Sandoval, C., Espinel, I., Guevara, A., Kennedy, M. W., Urban, Jr., Griffin, G. E., & Nutman, T. B.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-10
- Volume
- 182
- Issue
- 4
- Pages
- 1207-1213
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2104904969
- Cited by
- 256
- References
- 21
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Human Infection with Ascaris lumbricoides Is Associated with a Polarized Cytokine Response. https://app.cochat.ai/papers/10.1086/315830
- The paper
- Cooper, P. J., Chico, M. E., Sandoval, C., Espinel, I., Guevara, A., Kennedy, M. W., Urban, Jr., Griffin, G. E., & Nutman, T. B. (2000). Human Infection with Ascaris lumbricoides Is Associated with a Polarized Cytokine Response. The Journal of Infectious Diseases. https://doi.org/10.1086/315830
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
