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IgE responses to Ascaris and mite tropomyosins are risk factors for asthma

Ahumada, V., García, E., Dennis, R., Rojas, M. X., Rondón, M. A., Pérez, A., Peñaranda, A., Barragán, A. M., Jimenez, S., Kennedy, M. W., Caraballo, L.·2015·Clinical & Experimental Allergy
DOI 10.1111/cea.12513
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Abstract

Summary: Background: The relationship between helminthiases and allergy is a matter of considerable interest and research. In the tropics, house dust mite exposure, a known risk factor for asthma, is frequently concurrent with helminth infections. It remains to be defined whether infection with the common roundworm Ascaris or its bystander immunological effects influence the prevalence and pathogenesis of asthma independently of mite sensitization. Objective: To investigate the relationship between the IgE responses to Ascaris and its purified allergens and the risk of asthma in a tropical country. Methods: A nested case–control study was performed in 356 subjects who reported current and past asthma symptoms (asthmatics) and 435 controls that had never experienced such symptoms. They were tested for serum levels of total IgE and specific IgE to Ascaris extract, Asc s 1 (ABA‐1), Asc l 3 (tropomyosin) and GST (glutathione transferase). In addition, specific IgE to Dermatophagoides pteronyssinus, Blomia tropicalis and their tropomyosins Der p 10 and Blo t 10 was measured. Sensitization was defined as a positive specific IgE result to any extract or recombinant allergen. Results: Sensitization to Ascaris and D. pteronyssinus was independently associated with asthma after adjustment for age, gender, socio‐economic stratum, city and other IgE levels (adjusted OR s: 2.17; 95% CI 1.37–3.42 and 2.46; 95% CI 1.54–3.92), respectively. There was also a significant association with sensitization to the highly allergenic and cross‐reactive tropomyosins Asc l 3, Blo t 10 and Der p10 (aOR s: 1.76; 95% CI 1.21–2.57, 1.64; 95% CI 1.14–2.35 and 1.51; 95% CI 1.02–2.24), respectively. Conclusion and Clinical Relevance: IgE responses to Ascaris are associated with asthma symptoms in a population living in the tropics. Sensitization to the cross‐reactive Ascaris and mite tropomyosins partially underlies this finding. These results have potential relevance in asthma diagnosis and management.

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Metadata

Authors
Ahumada, V., García, E., Dennis, R., Rojas, M. X., Rondón, M. A., Pérez, A., Peñaranda, A., Barragán, A. M., Jimenez, S., Kennedy, M. W., & Caraballo, L.
Affiliations
  • Institute for Immunological Research University of Cartagena Cartagena Colombia
  • Division of Pediatric Allergy and Otorhinolaryngology Fundación Santafé de Bogotá Bogotá Colombia
  • Research Department Fundación Cardioinfantil – Instituto de Cardiología Bogotá Colombia
  • Department of Clinical Epidemiology and Biostatistics School of Medicine Pontificia Universidad Javeriana Bogotá Colombia
  • Division of Biostatistics School of Public Health University of Texas Health Science Center at Houston Houston TX USA
  • Institute of Biodiversity Animal Health and Comparative Medicine University of Glasgow Glasgow UK
Venue
Clinical & Experimental Allergy
Publisher
Wiley
Published
2015-06-17
Volume
45
Issue
7
Pages
1189-1200
ISSN
  • 0954-7894
  • 1365-2222
DOI
10.1111/cea.12513
Cited by
69
References
0
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
  • Cociencias (540–2008)
  • Colciencias (602-2009)

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CoChat. (2026). Citation check: IgE responses to Ascaris and mite tropomyosins are risk factors for asthma. https://app.cochat.ai/papers/10.1111/cea.12513
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Ahumada, V., García, E., Dennis, R., Rojas, M. X., Rondón, M. A., Pérez, A., Peñaranda, A., Barragán, A. M., Jimenez, S., Kennedy, M. W., & Caraballo, L. (2015). IgE responses to Ascaris and mite tropomyosins are risk factors for asthma. Clinical & Experimental Allergy. https://doi.org/10.1111/cea.12513