The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interactions between Herpes Simplex Virus Type 2 and Human Immunodeficiency Virus Type 1 Infection in African Women: Opportunities for Intervention
Open accessAbstract
Sexually transmitted diseases (STDs) are cofactors for human immunodeficiency virus (HIV) transmission, but the specific role of herpes simplex virus type 2 (HSV-2) is unclear. This study aimed to examine the in vivo relationships between HSV-2 and HIV-1 in 300 women in Bangui, Central African Republic. Sera were tested for syphilis, HIV-1, HSV-2 antibody, and levels of vitamins A and E. Genital specimens were tested for other STDs. HSV-2 DNA and HIV-1 RNA were quantified in cervicovaginal lavage. The prevalences of HSV-2 antibody (91% vs. 78%, P=.02), HSV-2 shedding (43% vs. 22%, P=. 003), and levels of HSV-2 DNA (P=.01) were all significantly higher among HIV-1-seropositive than among HIV-1-seronegative women. There was a significant correlation between genital HIV-1 RNA and HSV-2 DNA levels (P=.02) among the 23 women who were shedding HSV-2 DNA. If confirmed, such associations highlight the urgent need for HSV-2 control measures in populations at high risk of both infections.
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Cites
Fleming, D. T., & Wasserheit, J. N. (1999) · Sexually Transmitted Infections · doi:10.1136/sti.75.1.3 · Cited by 2,271
Cited by
Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.
Celum, C., Wald, A., Lingappa, J. R., Magaret, A. S., Wang, R. S., Mugo, N., Mujugira, A., Baeten, J. M., Mullins, J. I., Hughes, J. P., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0904849 · Cited by 524
Effect of Herpes Simplex Suppression on Incidence of HIV among Women in Tanzania
Watson-Jones, D., Weiss, H. A., Rusizoka, M., Changalucha, J., Baisley, K., Mugeye, K., Tanton, C., Ross, D., Everett, D., Clayton, T., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0800260 · Cited by 371
Self-citationHigh rates of syphilis among STI patients are contributing to the spread of HIV-1 in India.
Reynolds, S. J., Risbud, A. R., Shepherd, M. E., Rompalo, A. M., Ghate, M. V., Godbole, S. V., Joshi, S. N., Divekar, A. D., Gangakhedkar, R. R., Bollinger, R. C., et al. (2006) · Sexually Transmitted Infections · doi:10.1136/sti.2005.015040 · Cited by 95
Metadata
- Authors
- Mbopi‐Kéou, F., Grésenguet, G., Mayaud, P., Weiss, H. A., Gopal, R., Matta, M., Paul, J., Brown, D. W. G., Hayes, R. J., Mabey, D. C. W., & Bélec, L.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-10
- Volume
- 182
- Issue
- 4
- Pages
- 1090-1096
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2170264738
- Cited by
- 243
- References
- 1
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Interactions between Herpes Simplex Virus Type 2 and Human Immunodeficiency Virus Type 1 Infection in African Women: Opportunities for Intervention. https://app.cochat.ai/papers/10.1086/315836
- The paper
- Mbopi‐Kéou, F., Grésenguet, G., Mayaud, P., Weiss, H. A., Gopal, R., Matta, M., Paul, J., Brown, D. W. G., Hayes, R. J., Mabey, D. C. W., & Bélec, L. (2000). Interactions between Herpes Simplex Virus Type 2 and Human Immunodeficiency Virus Type 1 Infection in African Women: Opportunities for Intervention. The Journal of Infectious Diseases. https://doi.org/10.1086/315836
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
