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Cited by 371

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Effect of Herpes Simplex Suppression on Incidence of HIV among Women in Tanzania

Open access
Watson-Jones, Deborah, Weiss, Helen A., Rusizoka, Mary, Changalucha, John, Baisley, Kathy, Mugeye, Kokugonza, Tanton, Clare, Ross, David, Everett, Dean, Clayton, Tim, Balira, Rebecca, Knight, Louise, Hambleton, Ian, Le Goff, Jerome, Belec, Laurent, Hayes, Richard·2008·New England Journal of Medicine
DOI 10.1056/nejmoa0800260
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Abstract

BACKGROUND: Infection with herpes simplex virus type 2 (HSV-2) is associated with an increased risk of acquiring infection with the human immunodeficiency virus (HIV). This study tested the hypothesis that HSV-2 suppressive therapy reduces the risk of HIV acquisition. METHODS: Female workers at recreational facilities in northwestern Tanzania who were 16 to 35 years of age were interviewed and underwent serologic testing for HIV and HSV-2. We enrolled female workers who were HIV-seronegative and HSV-2-seropositive in a randomized, double-blind, placebo-controlled trial of suppressive treatment with acyclovir (400 mg twice daily). Participants attended mobile clinics every 3 months for a follow-up period of 12 to 30 months, depending on enrollment date. The primary outcome was the incidence of infection with HIV. We used a modified intention-to-treat analysis; data for participants who became pregnant were censored. Adherence to treatment was estimated by a tablet count at each visit. RESULTS: A total of 821 participants were randomly assigned to receive acyclovir (400 participants) or placebo (421 participants); 679 (83%) completed follow-up. Mean follow-up for the acyclovir and placebo groups was 1.52 and 1.62 years, respectively. The incidence of HIV infection was 4.27 per 100 person-years (27 participants in the acyclovir group and 28 in the placebo group), and there was no overall effect of acyclovir on the incidence of HIV (rate ratio for the acyclovir group, 1.08; 95% confidence interval, 0.64 to 1.83). The estimated median adherence was 90%. Genital HSV was detected in a similar proportion of participants in the two study groups at 6, 12, and 24 months. No serious adverse events were attributable to treatment with acyclovir. CONCLUSIONS: These data show no evidence that acyclovir (400 mg twice daily) as HSV suppressive therapy decreases the incidence of infection with HIV. (Current Controlled Trials number, ISRCTN35385041 [controlled-trials.com].).

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Metadata

Authors
Watson-Jones, D., Weiss, H. A., Rusizoka, M., Changalucha, J., Baisley, K., Mugeye, K., Tanton, C., Ross, D., Everett, D., Clayton, T., Balira, R., Knight, L., Hambleton, I., Le Goff, J., Belec, L., & Hayes, R.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2008-04-10
Volume
358
Issue
15
Pages
1560-1571
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa0800260
OpenAlex
W2114967009
Cited by
371
References
27
FWCI
47.30
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Effect of Herpes Simplex Suppression on Incidence of HIV among Women in Tanzania. https://app.cochat.ai/papers/10.1056/nejmoa0800260
The paper
Watson-Jones, D., Weiss, H. A., Rusizoka, M., Changalucha, J., Baisley, K., Mugeye, K., Tanton, C., Ross, D., Everett, D., Clayton, T., Balira, R., Knight, L., Hambleton, I., Le Goff, J., Belec, L., & Hayes, R. (2008). Effect of Herpes Simplex Suppression on Incidence of HIV among Women in Tanzania. New England Journal of Medicine. https://doi.org/10.1056/nejmoa0800260

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.