The DOI matches its Crossref record.
Serum Antibody as a Marker of Protection against Natural Rotavirus Infection and Disease
Abstract
To determine whether naturally acquired serum IgA and IgG antibodies were associated with protection against rotavirus infection and illness, a cohort of 200 Mexican infants was monitored weekly for rotavirus excretion and diarrhea from birth to age 2 years. Serum samples collected during the first week after birth and every 4 months were tested for anti-rotavirus IgA and IgG. Children with an IgA titer >1:800 had a lower risk of rotavirus infection (adjusted relative risk [aRR], 0.21; P<.001) and diarrhea (aRR, 0. 16; P=.01) and were protected completely against moderate-to-severe diarrhea. However, children with an IgG titer >1:6400 were protected against rotavirus infection (aRR, 0.51; P<.001) but not against rotavirus diarrhea. Protective antibody titers were achieved after 2 consecutive symptomatic or asymptomatic rotavirus infections. These findings indicate that serum anti-rotavirus antibody, especially IgA, was a marker of protection against rotavirus infection and moderate-to-severe diarrhea.
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Cited by
Safety and Efficacy of a Pentavalent Human–Bovine (WC3) Reassortant Rotavirus Vaccine
Vesikari, T., Matson, D. O., Dennehy, P., Van Damme, P., Santosham, M., Rodriguez, Z., Dallas, M. J., Heyse, J. F., Goveia, M. G., Black, S. B., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052664 · Cited by 1,873
Self-citationSantos, N., & Hoshino, Y. (2005) · Reviews in Medical Virology · doi:10.1002/rmv.448 · Cited by 1,251
Linhares, A. C., Velázquez, F. R., Pérez-Schael, I., Sáez-Llorens, X., Abate, H., Espinoza, F., López, P., Macías-Parra, M., Ortega-Barría, E., Rivera-Medina, D. M., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60524-3 · Cited by 379
Self-citationAnderson, E. J., & Weber, S. G. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)00928-4 · Cited by 351
Immunity and correlates of protection for rotavirus vaccines
Franco, M. A., Angel, J., & Greenberg, H. B. (2006) · Vaccine · doi:10.1016/j.vaccine.2005.12.048 · Cited by 268
Metadata
- Authors
- Velázquez, F. R., Matson, D. O., Guerrero, M. L., Shults, J., Calva, J. J., Morrow, A. L., Glass, R. I., Pickering, L. K., & Ruiz‐Palacios, G. M.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-12
- Volume
- 182
- Issue
- 6
- Pages
- 1602-1609
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2153862307
- Cited by
- 215
- References
- 0
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Velázquez, F. R., Matson, D. O., Guerrero, M. L., Shults, J., Calva, J. J., Morrow, A. L., Glass, R. I., Pickering, L. K., & Ruiz‐Palacios, G. M. (2000). Serum Antibody as a Marker of Protection against Natural Rotavirus Infection and Disease. The Journal of Infectious Diseases. https://doi.org/10.1086/317619
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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