The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cryptococcosis in Human Immunodeficiency Virus–Negative Patients in the Era of Effective Azole Therapy
Abstract
We conducted a case study of human immunodeficiency virus (HIV)-negative patients with cryptococcosis at 15 United States medical centers from 1990 through 1996 to understand the demographics, therapeutic approach, and factors associated with poor prognosis in this population. Of 306 patients with cryptococcosis, there were 109 with pulmonary involvement, 157 with central nervous system (CNS) involvement, and 40 with involvement at other sites. Seventy-nine percent had a significant underlying condition. Patients with pulmonary disease were usually treated initially with fluconazole (63%); patients with CNS disease generally received amphotericin B (92%). Fluconazole was administered to approximately two-thirds of patients with CNS disease for consolidation therapy. Therapy was successful for 74% of patients. Significant predictors of mortality in multivariate analysis included age > or =60 years, hematologic malignancy, and organ failure. Overall mortality was 30%, and mortality attributable to cryptococcosis was 12%. Cryptococcosis continues to be an important infection in HIV-negative patients and is associated with substantial overall and cause-specific mortality.
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Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Combination therapy with fluconazole and flucytosine for pulmonary cryptococcosis
Yamamoto, Y., Maesaki, S., Kakeya, H., Yanagihara, K., Ohno, H., Ogawa, K., Hirakata, Y., Tomono, K., Koga, H., Tashiro, T., et al. (2009) · Chemotherapy · doi:10.1159/000239603 · Cited by 20
Cited by
Perfect, J. R., Dismukes, W. E., Dromer, F., Goldman, D. L., Graybill, J. R., Hamill, R. J., Harrison, T. S., Larsen, R. A., Lortholary, O., Nguyen, M.-H., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/649858 · Cited by 2,660
Self-citationEpidemiology of Invasive Mycoses in North America
Pfaller, M. A., & Diekema, D. J. (2010) · Critical Reviews in Microbiology · doi:10.3109/10408410903241444 · Cited by 901
Mirza, S. A., Phelan, M., Rimland, D., Graviss, E., Hamill, R., Brandt, M. E., Gardner, T., Sattah, M., Ponce de Leon, G., Baughman, W., et al. (2003) · Clinical Infectious Diseases · doi:10.1086/368091 · Cited by 459
Self-citationThe Impact of Culture Isolation of Aspergillus Species: A Hospital‐Based Survey of Aspergillosis
Perfect, J. R., Cox, G. M., Lee, J. Y., Kauffman, C. A., de Repentigny, L., Chapman, S. W., Morrison, V. A., Pappas, P., Hiemenz, J. W., Stevens, D. A., et al. (2001) · Clinical Infectious Diseases · doi:10.1086/323900 · Cited by 458
Self-citationDeterminants of Disease Presentation and Outcome during Cryptococcosis: The CryptoA/D Study
Dromer, F., Mathoulin-Pélissier, S., Launay, O., Lortholary, O., & the French Cryptococcosis Study Group (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040021 · Cited by 374
Metadata
- Authors
- Pappas, P. G., Perfect, J. R., Cloud, G. A., Larsen, R. A., Pankey, G. A., Lancaster, D. J., Henderson, H., Kauffman, C. A., Haas, D. W., Saccente, M., Hamill, R. J., Holloway, M. S., Warren, R. M., & Dismukes, W. E.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-09
- Volume
- 33
- Issue
- 5
- Pages
- 690-699
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2116333471
- Cited by
- 642
- References
- 2
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cryptococcosis in Human Immunodeficiency Virus–Negative Patients in the Era of Effective Azole Therapy. https://app.cochat.ai/papers/10.1086/322597
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- Pappas, P. G., Perfect, J. R., Cloud, G. A., Larsen, R. A., Pankey, G. A., Lancaster, D. J., Henderson, H., Kauffman, C. A., Haas, D. W., Saccente, M., Hamill, R. J., Holloway, M. S., Warren, R. M., & Dismukes, W. E. (2001). Cryptococcosis in Human Immunodeficiency Virus–Negative Patients in the Era of Effective Azole Therapy. Clinical Infectious Diseases. https://doi.org/10.1086/322597
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
