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Cited by 431HIV/AIDS drug development and treatmentPharmacogenetics and Drug MetabolismComplementary and Alternative Medicine Studies

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

The Effect of Garlic Supplements on the Pharmacokinetics of Saquinavir

Piscitelli, Stephen C., Burstein, Aaron H., Welden, Nada, Gallicano, Keith D., Falloon, Judith·2002·Clinical Infectious Diseases
DOI 10.1086/324351
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Abstract

Herbal therapies are widely used, but there are few data on their interactions with conventional medications. This study evaluated the effect of garlic supplements on the pharmacokinetics of saquinavir. Ten healthy volunteers received 10 doses of saquinavir (Fortovase) at a dosage of 1200 mg 3 times daily with meals for 4 days on study days 1-4, 22-25, and 36-39, and they received a total of 41 doses of garlic caplets taken 2 times daily on study days 5-25. Blood samples were obtained on study days 4, 25, and 39 for determination of saquinavir plasma pharmacokinetic parameters. In the presence of garlic, the mean saquinavir area under the curve (AUC) during the 8-h dosing interval decreased by 51%, trough levels at 8 h after dosing decreased by 49%, and the mean maximum concentrations (Cmax) decreased by 54%. After the 10-day washout period, the AUC, trough, and Cmax values returned to 60%-70% of their values at baseline. Patients should use caution when combining garlic supplements with saquinavir when it is used as a sole protease inhibitor.

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Crossref · 10.1086/324351

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Research works printed but not linked: 4

  1. Foster BC, 2001, J Pharm Pharmeceut Sci, 4, 159
  2. Fitzsimmons ME, 1997, Drug Metab Dispos, 25, 256
  3. Kim AE, 1998, J Pharmacol Exp Ther, 286, 1439
  4. Choudhri SH, Gallicano K, Foster B, etal A study of pharmacokinetic interactions between garlic supplements and ritonavir in healthy volunteers [abstract 1637]. In: Program and abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy (Toronto). Washington, DC: American Society for Microbiology, 2000.

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Metadata

Authors
Piscitelli, S. C., Burstein, A. H., Welden, N., Gallicano, K. D., & Falloon, J.
Affiliations
National Institutes of Health (US)
ORCID
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2002-01-15
Volume
34
Issue
2
Pages
234-238
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/324351
OpenAlex
W2132806259
Cited by
431
References
14
Citations by year
2026: 4 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 12 · 2021: 11 · 2020: 14 · 2019: 11 · 2018: 4 · 2017: 7 · 2016: 11 · 2015: 13 · 2014: 25 · 2013: 20 · 2012: 27
FWCI
17.41
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
Keywords
garlic supplements, saquinavir, pharmacokinetics, drug interactions, herbal medicine, protease inhibitors, HIV antiretroviral therapy, plasma drug concentration, washout period
MeSH terms
Administration, Oral, Adult, Cytochrome P-450 Enzyme System, Drug Administration Schedule, Drug Combinations, Female, Garlic, Humans, Intestine, Small, Longitudinal Studies, Male, Plant Extracts, HIV-1, HIV Infections, Saquinavir, Dietary Supplements, Enterocytes

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