The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Risk of Human Immunodeficiency Virus Infection in Herpes Simplex Virus Type 2–Seropositive Persons: A Meta‐analysis
Abstract
To determine the contribution of herpes simplex type 2 (HSV-2) infection to the risk of human immunodeficiency virus (HIV) acquisition, a systematic review of literature and data synthesis were done. Thirty-one studies addressed the risk of HIV infection in HSV-2-seropositive persons. For 9 cohort and nested case-control studies that documented HSV-2 infection before HIV acquisition, the risk estimate was 2.1 (95% confidence interval, 1.4-3.2). Thus, the attributable risk percentage of HIV to HSV-2 was 52%, and the population attributable risk percentage was 19% in populations with 22% HSV-2 prevalence but increased to 47% in populations with 80% HSV-2 prevalence. For 22 case-control and cross-sectional studies, the risk estimate was 3.9 (95% confidence interval, 3.1-5.1), but the temporal sequence of the 2 infections cannot be documented. Control strategies for HSV-2 need to be incorporated into control of sexually transmitted infections as a strategy for HIV prevention.
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Cites
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Quantitative Synthesis in Systematic Reviews
Lau, J., Ioannidis, J. P. A., & Schmid, C. H. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-127-9-199711010-00008 · Cited by 2,517 · cited 1×
“As such, our study presents 2 main summary risk estimates, grouped by the study design [65].”
BackgroundHeterogeneity in Meta-analysis of Data from Epidemiologic Studies: A Commentary
Colditz, G. A., Burdick, E., & Mosteller, F. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117644 · Cited by 245
Cited by
Freeman, E. E., Weiss, H. A., Glynn, J. R., Cross, P. L., Whitworth, J. A., & Hayes, R. J. (2006) · AIDS · doi:10.1097/01.aids.0000198081.09337.a7 · Cited by 1,192
Once-daily valacyclovir to reduce the risk of transmission of genital herpes.
Corey, L., Wald, A., Patel, R., Sacks, S. L., Tyring, S. K., Warren, T., Douglas, J. M., Paavonen, J., Morrow, R. A., Beutner, K. R., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035144 · Cited by 720
Self-citation(2014) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-53488-0.00011-0 · Cited by 474
Celum, C., Wald, A., Hughes, J., Sanchez, J., Reid, S., Delany-Moretlwe, S., Cowan, F., Casapia, M., Ortiz, A., Fuchs, J., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60920-4 · Cited by 449
Self-citationChromatin control of herpes simplex virus lytic and latent infection
Knipe, D. M., & Cliffe, A. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1794 · Cited by 444
Metadata
- Authors
- Wald, A., & Link, K.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-01
- Volume
- 185
- Issue
- 1
- Pages
- 45-52
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2107555337
- Cited by
- 691
- References
- 4
- FWCI
- 27.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wald, A., & Link, K. (2002). Risk of Human Immunodeficiency Virus Infection in Herpes Simplex Virus Type 2–Seropositive Persons: A Meta‐analysis. The Journal of Infectious Diseases. https://doi.org/10.1086/338231
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