The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Clinical Trials of Immunomodulatory Therapies in Severe Sepsis and Septic Shock
Abstract
Sepsis remains one of the leading causes of mortality in critically ill patients. Increased insight into the complexities of this disease process has resulted in the targeting of various aspects of the inflammatory response as offering potential therapeutic benefits. There have been encouraging results in the past few years. Some of the tested agents have been shown to improve mortality rates in large randomized controlled trials involving patients with severe sepsis. In this article, we discuss the positive and negative results of trials in this field; some of the possible reasons for the negative results are examined, and directions for the future are suggested.
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Citations
Cites
Monocyte deactivation in septic patients: Restoration by IFN-γ treatment
Döcke, W.-D., Randow, F., Syrbe, U., Krausch, D., Asadullah, K., Reinke, P., Volk, H.-D., & Kox, W. (1997) · Nature Medicine · doi:10.1038/nm0697-678 · Cited by 1,190
Houdijk, A. P., Rijnsburger, E. R., Jansen, J., Wesdorp, R. I., Weiss, J. K., McCamish, M. A., Teerlink, T., Meuwissen, S. G., Haarman, H. J. T. M., Thijs, L. G., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02007-8 · Cited by 620
Galbán, C., Montejo, J. C., Mesejo, A., Marco, P., Celaya, S., Sánchez-Segura, J. M., Farré, M., & Bryg, D. J. (2000) · Critical Care Medicine · doi:10.1097/00003246-200003000-00007 · Cited by 404
The Effects of Intravenous Antioxidants in Patients With Septic Shock
Galley, H. F., Howdle, P. D., Walker, B. E., & Webster, N. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00059-2 · Cited by 203
Cited by
Novel strategies for the treatment of sepsis
Riedemann, N. C., Guo, R.-F., & Ward, P. A. (2003) · Nature Medicine · doi:10.1038/nm0503-517 · Cited by 773
The dark side of C5a in sepsis
Ward, P. A. (2004) · Nature Reviews Immunology · doi:10.1038/nri1269 · Cited by 422
Epidemiology and Immune Pathogenesis of Viral Sepsis
Lin, G.-L., McGinley, J. P., Drysdale, S. B., & Pollard, A. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02147 · Cited by 351
The changing immune system in sepsis: Is individualized immuno-modulatory therapy the answer?
Boomer, J. S., Green, J. M., & Hotchkiss, R. S. (2014) · Virulence · doi:10.4161/viru.26516 · Cited by 317
Sumaiya, K., Langford, D., Natarajaseenivasan, K., & Shanmughapriya, S. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108024 · Cited by 299
Metadata
- Authors
- Vincent, J., Sun, Q., & Dubois, M.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-04-15
- Volume
- 34
- Issue
- 8
- Pages
- 1084-1093
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W1984854267
- Cited by
- 228
- References
- 4
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
