The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
The changing immune system in sepsis: Is individualized immuno-modulatory therapy the answer?
Open accessAbstract
Sepsis remains the leading cause of death in most intensive care units. Advances in understanding the immune response to sepsis provide the opportunity to develop more effective therapies. The immune response in sepsis can be characterized by a cytokine-mediated hyper-inflammatory phase, which most patients survive, and a subsequent immune-suppressive phase. Patients fail to eradicate invading pathogens and are susceptible to opportunistic organisms in the hypo-inflammatory phase. Many mechanisms are responsible for sepsis-induced immuno-suppression, including apoptotic depletion of immune cells, increased T regulatory and myeloid-derived suppressor cells, and cellular exhaustion. Currently in clinical trial for sepsis are granulocyte macrophage colony stimulating factor and interferon gamma, immune-therapeutic agents that boost patient immunity. Immuno-adjuvants with promise in clinically relevant animal models of sepsis include anti-programmed cell death-1 and interleukin-7. The future of immune therapy in sepsis will necessitate identification of the immunologic phase using clinical and laboratory parameters as well as biomarkers of innate and adaptive immunity.
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Cites
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Self-citationGenomic responses in mouse models poorly mimic human inflammatory diseases
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Cited by
Bektas, A., Schurman, S. H., Franceschi, C., & Ferrucci, L. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00196-8 · Cited by 102
One population, multiple lifestyles: Commensalism and pathogenesis in the human mycobiome
Proctor, D. M., Drummond, R. A., Lionakis, M. S., & Segre, J. A. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.02.010 · Cited by 68
Metadata
- Authors
- Boomer, J. S., Green, J. M., & Hotchkiss, R. S.
- Venue
- Virulence
- Publisher
- Informa UK Limited
- Published
- 2013-09-25
- Volume
- 5
- Issue
- 1
- Pages
- 45-56
- ISSN
- 2150-5594 (ISSN-L)
- 2150-5608
- OpenAlex
- W2061730726
- Cited by
- 317
- References
- 147
- FWCI
- 12.32
- Type
- journal article
- Language
- en
- Open access
- gold
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- Boomer, J. S., Green, J. M., & Hotchkiss, R. S. (2014). The changing immune system in sepsis: Is individualized immuno-modulatory therapy the answer? Virulence. https://doi.org/10.4161/viru.26516
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
