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Cited by 494Mosquito-borne diseases and controlViral Infections and VectorsVirology and Viral Diseases

Differing Influences of Virus Burden and Immune Activation on Disease Severity in Secondary Dengue‐3 Virus Infections

Libraty, Daniel H., Endy, Timothy P., Houng, Huo‐Shu H., Green, Sharone, Kalayanarooj, Siripen, Suntayakorn, Saroj, Chansiriwongs, Wanya, Vaughn, David W. +3 more·2002·The Journal of Infectious Diseases
DOI 10.1086/340365
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Abstract

Dengue hemorrhagic fever (DHF), the most severe form of illness following infection with a dengue virus, is characterized by plasma leakage, thrombocytopenia, and hepatic inflammation. The interrelationships among virus burden, immune activation, and development of DHF were examined in 54 children with secondary dengue-3 virus infections participating in a prospective, hospital-based study. DHF was associated with higher mean plasma viremia early in illness and earlier peak plasma interferon-gamma levels. Maximum plasma viremia levels correlated with the degree of plasma leakage and thrombocytopenia. Maximum plasma levels of interleukin (IL)-10 and soluble tumor necrosis factor receptor-II correlated with the degree of thrombocytopenia, independently of viremia levels. Hepatic transaminase elevation correlated with plasma soluble IL-2 receptor levels and not with viremia levels. Quantitative differences in virus burden and host immune responses, and the timing of type 1 cytokine responses, have differing influences on the severity of disease manifestations during secondary dengue-3 virus infections.

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  • Serum concentrations of IFN-alpha, IFN-gamma, IL-10, and TNF receptors are elevated in the early phase of dengue and remain elevated until defervescence occurs.

    “Serum concentrations of IFN-␣, IFN-␥, IL-10, and TNF receptors are elevated in this early phase and remain elevated until defervescence occurs (86).”

    From Into the Eye of the Cytokine Storm (2012) · cites this paper as [86]

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Research works printed but not linked: 5

  1. Huang YH, Liu CC, Wang ST, et al. Activation of coagulation and fibrino- lysis during dengue virus infection. J Med Virol 2001; 63:247-51.
  2. Guzman MG, Kouri GP, Bravo J, Soler M, Vazquez S, Morier L. Dengue hemorrhagic fever in Cuba. Am J Trop Med Hyg 1990; 42:179-84.
  3. Sudiro TM, Zivny J, Ishiko H, et al. Analysis of plasma viral RNA levels during acute dengue virus infection using quantitative competitor re- verse transcription-polymerase chain reaction. J Med Virol 2001; 63: 29-34.
  4. Green S, Vaughn DW, Kalayanarooj S, et al. Elevated plasma interleukin- 10 levels in acute dengue correlate with disease severity. J Med Virol 1999; 59:329-34.
  5. Kurane I, Innis BL, Nimmannitya S, et al. Activation of T lymphocytes in dengue virus infections. J Clin Invest 1991; 88:1473-80.

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Authors
Libraty, D. H., Endy, T. P., Houng, H. H., Green, S., Kalayanarooj, S., Suntayakorn, S., Chansiriwongs, W., Vaughn, D. W., Nisalak, A., Ennis, F. A., & Rothman, A. L.
Affiliations
  • University of Massachusetts Chan Medical School (US)
  • Armed Forces Research Institute of Medical Science (TH)
  • Walter Reed Army Institute of Research (US)
  • Queen Sirikit National Institute of Child Health (TH)
  • Kamphaeng Phet Hospital (TH)
Corresponding author
Libraty, Daniel H.
ORCID
Venue
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2002-05
Volume
185
Issue
9
Pages
1213-1221
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1086/340365
OpenAlex
W2110628545
Cited by
494
References
60
Citations by year
2026: 6 · 2025: 10 · 2024: 9 · 2023: 13 · 2022: 7 · 2021: 15 · 2020: 27 · 2019: 16 · 2018: 13 · 2017: 27 · 2016: 29 · 2015: 35 · 2014: 37 · 2013: 27 · 2012: 35
FWCI
13.60
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship@UMassChan (submittedVersion)
Funders
National Institute of Allergy and Infectious Diseases (AI-34533, P01AI034533)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
dengue hemorrhagic fever, secondary dengue infection, disease severity, plasma viremia, immune activation, interferon-gamma, IL-10, soluble tumor necrosis factor receptor II, soluble interleukin-2 receptor, thrombocytopenia, plasma leakage, hepatic transaminase elevation, Th1 cytokines, children
MeSH terms
Child, Female, Humans, Interferon-gamma, Male, Prospective Studies, Viremia, Antigens, CD, Multivariate Analysis, Interleukin-10, DNA, Complementary, Receptors, Tumor Necrosis Factor, Viral Load, Severe Dengue, Reverse Transcriptase Polymerase Chain Reaction, Receptors, Tumor Necrosis Factor, Type II

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