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Resistance among Streptococcus pneumoniae:Implications for Drug Selection
Open accessAbstract
Streptococcus pneumoniae is an important pathogen in many community-acquired respiratory infections in the United States and a leading cause of morbidity and mortality worldwide. Unfortunately, S. pneumoniae is becoming increasingly resistant to a variety of antibiotics. Results of recent surveillance studies in the United States show that the prevalence of penicillin-nonsusceptible S. pneumoniae ranges from 25% to >50%, and rates of macrolide resistance among pneumococci are reported to be as high as 31%. A high prevalence of resistance to other antimicrobial classes is found among penicillin-resistant strains. Newer quinolones (e.g., gatifloxacin, gemifloxacin, and moxifloxacin) that have better antipneumococcal activity in vitro are the most active agents and therefore are attractive options for treatment of adults with community-acquired respiratory infections. Efforts should be made to prevent pneumococcal infections in high-risk patients through vaccination.
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Burdett, V (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)49928-0 · Cited by 141
Cited by
The quinolones: decades of development and use
Emmerson, A. M. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg208 · Cited by 531
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
Brötz-Oesterhelt, H., Beyer, D., Kroll, H.-P., Endermann, R., Ladel, C., Schroeder, W., Hinzen, B., Raddatz, S., Paulsen, H., Henninger, K., et al. (2005) · Nature Medicine · doi:10.1038/nm1306 · Cited by 505
Fluoroquinolones, tuberculosis, and resistance
Ginsburg, A. S., Grosset, J. H., & Bishai, W. R. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00671-6 · Cited by 403
Knapp, S., Wieland, C. W., van ’t Veer, C., Takeuchi, O., Akira, S., Florquin, S., & van der Poll, T. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.3132 · Cited by 268
Metadata
- Authors
- Appelbaum, P. C.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-06-15
- Volume
- 34
- Issue
- 12
- Pages
- 1613-1620
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2143391752
- Cited by
- 260
- References
- 1
- FWCI
- 21.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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