The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Toll-Like Receptor 2 Plays a Role in the Early Inflammatory Response to Murine Pneumococcal Pneumonia but Does Not Contribute to Antibacterial Defense
Abstract
Toll-like receptors (TLR) are crucial pattern recognition receptors in innate immunity. The importance of TLR2 in host defense against Gram-positive bacteria has been suggested by the fact that this receptor recognizes major Gram-positive cell wall components, such as peptidoglycan and lipoteichoic acid. To determine the role of TLR2 in pulmonary Gram-positive infection, we first established that TLR2 is indispensable for alveolar macrophage responsiveness toward Streptococcus pneumoniae. Nonetheless, TLR2 gene-deficient mice intranasally inoculated with S. pneumoniae at doses varying from nonlethal (with complete clearance of the infection) to lethal displayed only a modestly reduced inflammatory response in their lungs and an unaltered antibacterial defense when compared with normal wild-type mice. These data suggest that TLR2 plays a limited role in the innate immune response to pneumococcal pneumonia, and that additional pattern recognition receptors likely are involved in host defense against this common respiratory pathogen.
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Cites
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 6×
“Thus, the roles of, for example, TLR6 and TLR1, which can form heterodimers with TLR2 for optimal detection of some Gram-positive PAMPs (18, 45), and TLR9, which recognizes bacterial DNA (46), in S.”
BackgroundInfluentialSelf-citationTakeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Self-citationToll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80119-3 · Cited by 3,362
Self-citationToll-like receptors in the induction of the innate immune response
Aderem, A., & Ulevitch, R. J. (2000) · Nature · doi:10.1038/35021228 · Cited by 3,064
Practice Guidelines for the Management of Community-Acquired Pneumonia in Adults
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Ozinsky, A., Underhill, D. M., Fontenot, J. D., Hajjar, A. M., Smith, K. D., Wilson, C. B., Schroeder, L., & Aderem, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250476497 · Cited by 2,085
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Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2
Schwandner, R., Dziarski, R., Wesche, H., Rothe, M., & Kirschning, C. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17406 · Cited by 1,704
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
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Cited by
The Gut Microbiota Plays a Protective Role in the Host Defence Against Pneumococcal Pneumonia
Schuijt, T. J., Lankelma, J. M., Scicluna, B. P., de Sousa e Melo, F., Roelofs, J. J. T. H., de Boer, J. D., Hoogendijk, A. J., de Beer, R., de Vos, A., Belzer, C., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309728 · Cited by 832
Pathogenesis, treatment, and prevention of pneumococcal pneumonia
van der Poll, T., & Opal, S. M. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61114-4 · Cited by 720
Self-citationAcute Lower Respiratory Tract Infection
Mizgerd, J. P. (2008) · New England Journal of Medicine · doi:10.1056/nejmra074111 · Cited by 441
Xu, H., Sobue, T., Thompson, A., Xie, Z., Poon, K., Ricker, A., Cervantes, J., Diaz, P. I., & Dongari‐Bagtzoglou, A. (2014) · Cellular Microbiology · doi:10.1111/cmi.12216 · Cited by 179
Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes
Warszawska, J. M., Gawish, R., Sharif, O., Sigel, S., Doninger, B., Lakovits, K., Mesteri, I., Nairz, M., Boon, L., Spiel, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67911 · Cited by 148
Self-citation
Metadata
- Authors
- Knapp, S., Wieland, C. W., van ’t Veer, C., Takeuchi, O., Akira, S., Florquin, S., & van der Poll, T.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-03-01
- Volume
- 172
- Issue
- 5
- Pages
- 3132-3138
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1550704138
- Cited by
- 268
- References
- 45
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Toll-Like Receptor 2 Plays a Role in the Early Inflammatory Response to Murine Pneumococcal Pneumonia but Does Not Contribute to Antibacterial Defense. https://app.cochat.ai/papers/10.4049/jimmunol.172.5.3132
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- Knapp, S., Wieland, C. W., van ’t Veer, C., Takeuchi, O., Akira, S., Florquin, S., & van der Poll, T. (2004). Toll-Like Receptor 2 Plays a Role in the Early Inflammatory Response to Murine Pneumococcal Pneumonia but Does Not Contribute to Antibacterial Defense. The Journal of Immunology. https://doi.org/10.4049/jimmunol.172.5.3132
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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