The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Respiratory Syncytial Virus–Induced Activation of Nuclear Factor–κB in the Lung Involves Alveolar Macrophages and Toll‐Like Receptor 4–Dependent Pathways
Abstract
The transcription factor nuclear factor (NF)-kappaB controls the expression of numerous respiratory syncytial virus (RSV)-inducible inflammatory and immunomodulatory genes. Using a BALB/c mouse model, the present article shows that RSV potently and specifically activates NF-kappaB in vivo, a process that involves nuclear translocation of the subunits RelA, p50, and c-Rel in the lung. By depletion of alveolar macrophages (AMs) in BALB/c mice and use of C3H/HeJ mice lacking a functional Toll-like receptor (TLR)-4 signaling pathway, we demonstrate the existence of distinct but sequentially integrated RSV-inducible early NF-kappaB responses in the lung. The first response occurs early after RSV inoculation, is AM and TLR4 dependent, and is viral replication independent, whereas the second response involves epithelial cells and/or inflammatory cells, is TLR4 independent, and requires viral replication. NF-kappaB may be considered a central activator of not only inflammatory but also innate immune responses to RSV.
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“RSV was shown to induce Pseudomonas aeruginosa, S. pneumoniae, and H. influenzae adherence to airway epithelial cells (12, 70, 95, 292)”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [95]
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
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Toll-like receptors: critical proteins linking innate and acquired immunity
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Toll-like receptors in the induction of the innate immune response
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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
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Respiratory Syncytial Virus and Parainfluenza Virus
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Imai, Y., Kuba, K., Neely, G. G., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, Y. H. C., Wang, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.043 · Cited by 1,356
Pattern Recognition Receptors and the Innate Immune Response to Viral Infection
Thompson, M., Kaminski, J. J., Kurt‐Jones, E. A., & Fitzgerald, K. A. (2011) · Viruses · doi:10.3390/v3060920 · Cited by 845
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
Respiratory Syncytial Virus—A Comprehensive Review
Borchers, A. T., Chang, C. C.-C., Gershwin, M. E., & Gershwin, L. J. (2013) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-013-8368-9 · Cited by 666
Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease
Schröder, N. W. J., & Schumann, R. R. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)01308-3 · Cited by 638
Metadata
- Authors
- Haeberle, H. A., Takizawa, R., Casola, A., Brasier, A. R., Dieterich, H., van Rooijen, N., Gatalica, Z., & Garofalo, R. P.
- Affiliations
- Universitätsklinikum Tübingen (DE)
- Pediatrics and Genetics (US)
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-11
- Volume
- 186
- Issue
- 9
- Pages
- 1199-1206
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2101292818
- Cited by
- 237
- References
- 42
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 13 · 2016: 4 · 2015: 6 · 2014: 14 · 2013: 11 · 2012: 9
- FWCI
- 12.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ai015939-17, 5p01ai046004-04)
- National Institute of Allergy and Infectious Diseases (AI46004, AI 15939)
- Topics
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- respiratory syncytial virus, NF-κB activation, alveolar macrophages, TLR4, lung innate immunity, p65 nuclear translocation, epithelial cells, C3H/HeJ mice, BALB/c mouse model
- MeSH terms
- Animals, Humans, Lung, Membrane Glycoproteins, Mice, Inbred BALB C, Mice, Inbred C3H, Receptors, Cell Surface, Respiratory Syncytial Viruses, NF-kappa B, Macrophages, Alveolar, Respiratory Syncytial Virus Infections, Protein Subunits, Drosophila Proteins, Toll-Like Receptors, Toll-Like Receptor 4, Mice
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