The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Addition of a Macrolide to a β‐Lactam–Based Empirical Antibiotic Regimen Is Associated with Lower In‐Hospital Mortality for Patients with Bacteremic Pneumococcal Pneumonia
Abstract
To assess the association between inclusion of a macrolide in a beta-lactam-based empirical antibiotic regimen and mortality among patients with bacteremic pneumococcal pneumonia, 10 years of data from a database were analyzed. The total available set of putative prognostic factors was subjected to stepwise logistic regression, with in-hospital death as the dependent variable. Of the 409 patients analyzed, 238 (58%) received a beta-lactam plus a macrolide and 171 (42%) received a beta-lactam without a macrolide. Multivariate analysis revealed 4 variables to be independently associated with death: shock (P<.0001), age of >or=65 years (P=.02), infections with pathogens that have resistance to both penicillin and erythromycin (P=.04), and no inclusion of a macrolide in the initial antibiotic regimen (P=.03). For patients with bacteremic pneumococcal pneumonia, not adding a macrolide to a beta-lactam-based initial antibiotic regimen is an independent predictor of in-hospital mortality. However, only a randomized study can definitively determine whether this association is due to a real effect of macrolides.
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Cites
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Severe Community-acquired Pneumonia: Epidemiology and Prognostic Factors
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Bacteremic pneumococcal pneumonia in one American city: a 20-year longitudinal study, 1978–1997
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Amsden, G. W. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh519 · Cited by 409
Progress in the mechanism and targeted drug therapy for COPD
Wang, C., Zhou, J., Wang, J., Li, S., Fukunaga, A., Yodoi, J., & Tian, H. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00345-x · Cited by 303
Metersky, M. L., Masterton, R. G., Lode, H., File, T. M., & Babinchak, T. (2012) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2012.01.003 · Cited by 293
Metadata
- Authors
- Martinez, J. A., Horcajada, J. P., Almela, M., Marco, F., Soriano, A., Garcia, E., Marco, M. A., Torres, A., & Mensa, J.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-02-15
- Volume
- 36
- Issue
- 4
- Pages
- 389-395
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2131062756
- Cited by
- 357
- References
- 11
- FWCI
- 23.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Martinez, J. A., Horcajada, J. P., Almela, M., Marco, F., Soriano, A., Garcia, E., Marco, M. A., Torres, A., & Mensa, J. (2003). Addition of a Macrolide to a β‐Lactam–Based Empirical Antibiotic Regimen Is Associated with Lower In‐Hospital Mortality for Patients with Bacteremic Pneumococcal Pneumonia. Clinical Infectious Diseases. https://doi.org/10.1086/367541
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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